CIMmic® OH 0.1 mL Disk (Hydroxyl) (2 µm channels) - Pack of 3

CIMmic^® OH relies on hydrophobic interaction chromatography (HIC) to provide an excellent screening solution for the purification of large biomolecules, such as virus particles, LNPs, VLPs and extracellular vesicles.

CIMmic^® is a line of small monoliths that provide an easy, budget‑friendly way to perform monolith chromatography using standard lab equipment. It offers an effortless way to start your process development.

CIMmic is a line of small monoliths that provide an easy, budget‑friendly way to perform monolith chromatography using standard lab equipment. It offers an effortless way to start your process development.

The CIMmic line is the accessible entry point into CIM monolith chromatography for laboratories that need fast, flexible, and meaningful process development at small scale. Designed for early‑stage method development and focused parameter screening, CIMmic helps scientists evaluate purification conditions without the need for complex automation, large sample volumes, or extensive chromatography infrastructure.

OH features:

• Uncharged (neutral) ligand
• Working range, pH 2–10
• Retains very large solutes (virus particles, VLP, vesicles) in the presence of precipitating salts or polyethylene glycol, and elutes them with high resolution in order of increasing size
• Can be used as a pre-capture step to reduce most host cell impurities in AAV purification
• Elution with descending salt or polyethylene glycol
• Sanitizable with 1 M NaOH

Benefits:

• Very fast processes by convective mass transport – resolution independent of flow
• High capacity for large molecules due to fully accessible void volume in the channels
• Laminar flow minimizes shear stress, resulting in high yields
• Ideal for early process development and feasibility testing
• Operable by syringe or FPLC
• Low sample and buffer consumption