CIMmic® SO3 0.1 mL Disk (Sulfonate) (2 µm channels) - Pack of 3

CIMmic^® SO3 disk provides an excellent solution for screening chromatographic conditions for the purification of biomolecules such as viruses, adeno-associated viruses (AAV), and virus-like particles (VLP) via ionic interactions with the monolith.

CIMmic is a line of small monoliths that provide an easy, budget‑friendly way to perform monolith chromatography using standard lab equipment. It offers an effortless way to start your process development.

The CIMmic line is the accessible entry point into CIM^® monolith chromatography for laboratories that need fast, flexible, and meaningful process development at small scale. Designed for early‑stage method development and focused parameter screening, CIMmic helps scientists evaluate purification conditions without the need for complex automation, large sample volumes, or extensive chromatography infrastructure.

SO3 (sulfonate) features:

• Strong cation exchanger
• Working range, pH 2–13
• Binds molecules with predominantly positive charge, repels molecules a predominantly negative charge
• Use for capture, intermediate, or polishing steps in either bind-elute or flow-through mode
• Main application: AAV capture step
• High capacity for purification of virus and VLP particles, large proteins
• Sanitizable with 1 M NaOH

Benefits:

• Very fast processes by convective mass transport – resolution independent of flow
• High-capacity for large molecules due to fully accessible void volume in the channels
• Laminar flow minimizes shear stress resulting in high yields
• Ideal for early process development and feasibility testing
• Operable by syringe or FPLC
• Low sample and buffer consumption