Resolute® Flowdrive MU chromatography systems are stainless-steel, low-pressure liquid chromatography systems developed for multi-use batch purification in biopharmaceutical manufacturing. Designed to meet the demands of both clinical and commercial production environments, the platform combines proven hardware, flexible configurations, and extensive customization options to accommodate evolving process needs.
Formats
M: 20–400 L/h
L: 30–1,200 L/h
XL: 60–2,500 L/h
XXL: 150–5,000 L/h
The systems are suitable for purification processes using both traditional chromatography columns and membrane-based consumables. Standard two-pump configurations support in-line dilution (ILD) and gradient formation, while single-pump options enable isocratic operation where simplified process control is preferred.
Applications
- Clinical- and commercial-scale purification of monoclonal antibodies (mAbs)
- Recombinant protein purification
- Blood plasma processing
- Vaccine manufacturing
- Capture and polishing chromatography operations
Key advantages
- Flexible platform compatible with both membrane and column applications
- Broad flow-rate portfolio supporting scale-up from clinical to commercial manufacturing
- Configurable system architecture tailored to specific process requirements
- Advanced functionality including gradient control and in-line dilution capabilities
- Comprehensive process monitoring to support reproducibility and process control
- CE- or UL-compliant designs, with additional certifications available upon request
- Customization options such as inline mixers, pressure control, enhanced UV detection, and fraction collection configurations
- Engineered-to-order solutions available for specialized requirements, including in-line conditioning, medium-pressure liquid chromatography (MPLC), explosion-proof designs, and steam-in-place (SIP) capability