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CIMmultus® C4 HLD 8000 mL Monolithic Column (2 μm)

Tech Support Documents
CIMmultus® C4 HLD 8000 mL Monolithic Column (2 μm)
 

CIMmultus® C4 HLD employs a high density of butyl ligands to achieve strong surface hydrophobicity. Relying on hydrophobic interaction chromatography (HIC), this column is a must for nucleic acid separations, providing an excellent solution for the purification of pDNA and RNA.

GMP Compliance
Volume
Channel Size
Item No.: 
1011.8136-2
Piece
1
*Custom/bulk order quotes are provided within 72 hours of request.
CIMmultus® C4 HLD 8000 mL Monolithic Column (2 μm)
CIMmultus® C4 HLD 8000 mL Monolithic Column (2 μm)

CIMmultus® C4 HLD employs a high density of butyl ligands to achieve strong surface hydrophobicity. Relying on hydrophobic interaction chromatography (HIC), this column is a must for nucleic acid separations, providing an excellent solution for the purification of pDNA and RNA.

Item No.:
1011.8136-2
Number of pieces
1

Overview

Specifications

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CIMmultus® is a unique and industry-proven line of pre-packed chromatographic monolithic columns featuring large flow-through channels, designed for working with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), virus-like particles and exosomes. CIMmultus® columns can be used as single-use disposable or multi-use columns. They are available in a variety of volume ranges – from 1mL for screening and method development purposes to 8000mL for industrial manufacturing.

CIMmultus® C4 HLD employs a high density of butyl ligands to achieve strong surface hydrophobicity. Relying on hydrophobic interaction chromatography (HIC), this column is a must for nucleic acid separations, providing an excellent solution for the purification of pDNA and RNA.

C4 (butyl) high ligand density (HLD) features:

  • Strongly hydrophobic, uncharged
  • Working range, pH 2–10
  • Highly effective for removing proteins from nucleic acids (pDNA, RNA)

Your benefits:

  • Very fast processes by convective mass transport
  • Resolution independent of flow
  • Ready to use columns
  • High-capacity for large molecules due to fully accessible void volume in the channels
  • Laminar flow minimizes shear stress resulting in high yields

Applications

  • Application
    Preparative Applications

Compliance Information

  • GMP Compliance
    non-cGMP

Connections (Physical)

  • Connector(s)
    TC 1" (25 mm), 8 mm ID bore

Dimensions

  • Channel Size
    2 µm
  • Column Tube Length
    410 mm
  • Inner Diameter
    255 mm
  • Outer Diameter
    300 mm

Features

  • Reusable
    Yes

General Specifications

  • Flow Rate
    800–8000 mL/min | 13–135 cm/h | 0.1–1 CV/min

Materials of Construction

  • Materials of Construction
    Poly(butyl methacrylate -co- ethylene dimethacrylate)

Operating Conditions

  • Maximum Operating Pressure
    0.7 MPa | 7 bar | 100 psi
  • Recommended Operating Temperature
    4 °C (39 °F) to 40 °C (104 °F)
  • pH Stability
    Working range 3–13, cleaning in place 1–14

Physicochemical Information

  • Bed Volume
    8000 mL
  • Ligand
    C4 HLD (hydrophobic, butyl – high ligand density)

Product Information

  • Brand
    CIMmultus®
  • Package Type
    Individually Packed

Volume

  • Volume
    8000 mL