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Analytical Chromatography (22)
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Labware holder: 15 mL centrifuge tube holder with lid (holds 24x tubes)
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PATfix® LNP Switcher is a chromatography-based analytical platform tailored for lipid nanoparticle (LNP) characterization, enabling at-line determination of encapsulation efficiency, particle size, and lipid composition to accelerate nucleic acid–based therapeutic development.
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PATfix® pDNA Platform: A chromatography-based analytical solution tailored for plasmid DNA (pDNA) processing, enabling rapid at-line isoforms (open circular, supercoiled, linear) and multimer separation, quantification, and process control across all stages.
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PATfix® mRNA Platform: A chromatography-based analytical platform tailored for mRNA characterization, enabling at-line IVT reaction monitoring, rapid quantification, and comprehensive quality control (size, integrity, dsRNA) to accelerate nucleic acid therapeutic development.
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Biocompatible analytical chromatography system with quaternary buffer setup.
PATfix® analytical quaternary system is an at-line tool, to help process developers of novel gene therapies get immediate feedback on their current process state. This enables faster iteration and process optimization towards better purities and higher recoveries. The Sartorius analytical system provides modality-appropriate analysis and in-process control for gene therapy and vaccine products. Designed to take full advantage of the capabilities of CIMac™ analytical monolithic columns, the PATfix® delivers fast, high-resolution runs. Operation with multiple detector types provides content- rich analyses even with complex samples. User friendly PATfix® software makes for easy data processing, visualization and sharing.
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The mFix4 mRNA standard is a 3969 nt long mRNA molecule with a poly-adenylated tail of 95 nt. The molecule is produced by IVT reaction with a DNA template retrieved from recombinant microbial expression (E. coli). Its primary use is System Suitability Testing.
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