Virosart® Media Mid-Scale Module 0.3 m² - Sterile Delivery

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Virosart® Media Mid-Scale Module 0.3 m² - Sterile Delivery Virosart® Media Mid-Scale Module 0.3 m² - Sterile Delivery Virosart® Media Mid-Scale Module 0.3 m² - Sterile Delivery Virosart® Media Mid-Scale Module 0.3 m² - Sterile Delivery Virosart® Media Mid-Scale Module 0.3 m² - Sterile Delivery
 

First virus retentive filter for cell culture media.

Protect your cell culture media from virus contaminations with the 20 nm high flux PES Virosart® Media. The filter retains ≥ 4 LRV for small non-enveloped viruses like MVM or Vesivirus and ≥ 6 LRV for large enveloped viruses.

Delivery Condition
Item No.: 
3V2--28-GVGFO
Availability: 

*Custom/bulk order quotes are provided within 72 hours of request.

Poster

Mitigate Virus Contamination Risks for Advanced Therapies

Ensuring virus-free raw materials for ATMP production by integrating nanofiltration as an upstream risk mitigation tool.

Download Poster

Application:

  • Target molecule: The main application for Virosart® Media is virus retentive filtration of chemically defined cell culture media.
  • Virus clearance: Virosart® Media targets the removal of small non-enveloped adventitious viruses (20 nm) e.g. MVM or vesivirus from chemically defined cell culture media.
  • Positioning: Virosart® Media is used after the media preparation step itself before transferring the media into the bioreactor. This can be operated either as in-line filtration (e.g. perfusion) or batch filtration. Performance of the Virosart® Media is independent of the use of powder or liquid media but could be strongly impacted by the media itself. Virosart® Media is optimized for chemically defined media. Protein transmission for mAbs and recombinant proteins is not given for this filter.

Product benefits:

  • Robust virus clearance: Virosart® Media provides high virus safety to the bioreactor as it is qualified for ≥ 4 LRV (Log10 reduction value) of small non-enveloped viruses (e.g. MVM) and ≥ 6 LRV for large enveloped viruses.
  • Short processing times: Based on the optimized Polyethersulfone membrane, Virosart® Media provides highest flow rates and excellent capacity for cell culture media (e.g. ≥ 1000 L/m2 in 4 h).
  • Smart process transfer: The hollow fiber format supplies highest consistency and scalability from lab to process scale.
  • Cost efficiency: The high packing density of the elements combines extremely low hold up with low footprint requirements.
  • Ready to use: The sterile delivery secures ease of use as well as fast installation of the filter elements.
  • Ease of use: Virosart® Media are tested for integrity using a water-based diffusion test, e.g. based on the Sartocheck® technology of Sartorius Stedim Biotech

Regulatory Compliance

  • Each individual module is tested for integrity and for water flow rate during manufacturing
  • Validated for ≥ 4 LRV removal of small non-enveloped viruses using bacteriophage PP7
  • Designed, developed and manufactured in accordance with an ISO 9001 certified Quality Management System
  • Meet or exceed the requirements for WFI quality standards set by the current USP
  • Non pyrogenic according to USP Bacterial Endotoxins
  • USP Plastic Class Test VI

Applications

  • Application
    Cell Culture Media Filtration

Connections (Physical)

  • Connector Inlet
    3/4" Tri-clamp 25 mm
  • Connector Outlet
    Hose Barb

Dimensions

  • Filtration Area
    0.3 m² | 3.2 ft²

Features

  • Integrity Tested
    Yes

General Specifications

  • Capsule/Cartridge Format
    Filter capsule
  • Filter Format
    Filter Capsules

Materials of Construction

  • Filter Material
    Polyethersulfone (PES)

Physicochemical Information

  • Pore Size
    20 nm (nominal)

Product Information

  • Brand
    Virosart® Media
  • Pack Size
    1

Sterility/Purity

  • Delivery Condition
    Sterile - Gamma irradiated