Sartoclean® GF | Sartoscale 47 | 0.65µm | 3pc.

The Sartoclean^® family is a cellulose acetate (CA) membrane based prefilter. These filters are optimized for the protection of downstream equipment and Sartobran^® cellulose acetate final filters.

Main Applications

Sartoclean^® GF filters are widely used in the field of pre-filtration of biotechnological manufacturing processes to protect the subsequent downstream process instruments. Typical applications include both bioburden reduction and effective removal of colloids and lipids from:

• Fermentation solutions
• Serum
• Plasma
• Cell culture medium
• Solutions containing colloids and lipids

SartoScale units are ideally suited for all types of filterability studies with the aim of selecting the optimal prefilter for an optimal application. Moreover, they can determine the ideal combination of pre- and final filters with the aid of a minimum product volume.

• Developed for the execution of reliable filterability samples
• Made from the same non-woven fabric material as the original filter cartridges
• Ready-to-use single-use test filter unit

Membrane

The heterogeneous double layer CA membrane increases the total throughput performance by having a "built-in pre-filtration", which results in the highest possible total flow, so that a filter change during filtration is avoided.

The membrane is protected by a layer of highly absorbent glass fleece, which adds an adsorptive component to your filtration process.

Sartoscale units contain the original filter active material of the corresponding filter cartridges to ensure the repeatability of test results.

Flexibility

Sartoclean^® GF filters are available in a wide range of filtration areas from 4.5 cm² up to 1.41 m² and with a variety of commonly used connections to ensure easy integration into your process regardless of batch size.

Using Sartoscale during filtration studies saves time which would otherwise be used for the installation preparations for the punch piece in the stainless steel filter brackets and prevents possible installation errors.

After the material selection or the definition of a pre/final filter combination with the Sartoscale units, a scale-up method should be carried out for the flow rate and total flow using pleated capsule units of small scales (e.g. capsule size 4).

Sartoscale units have an extremely low residual volume for performing filterability samples with minimized product volumes.

Sartoscale test filter units are equipped with suitable filter membranes for integrity testing so that their integrity can be determined using the bubble point test in order to ensure absolute reliability of the test results.

We recommend using the Sartoscale units together with the Zero-T Filter Test System to make the filtration studies as effective as possible. The Zero-T system consists of hardware and software modules which make it easy to handle and install Sartoscale test filter units. Automatic data collection is achieved by connecting a frame to a laptop. The software automatically analyzes the incoming data for the scale-up calculations.