Sartobind® S Nano 1 mL with 4 mm bed height

Sartobind® S membrane adsorber units combine the advantages of convective media and ion exchange chromatography for rapid and easy contaminant removal or capture of virus and virus like particles.

Bed Volume
Connector(s)
Pack Size
Item No.: 
96IEXS42DN-11--A
Availability: 

*Custom/bulk order quotes are provided within 72 hours of request.

Sartobind® S membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Sulfonic acid ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.

Applications:

The S membrane adsorber is successfully used in FDA-approved drug manufacture to remove host cell proteins at high flow rates. As a cation exchanger it displays not only aggregate removal capabilities but typically at least ten-fold higher binding capacity for viruses and virus-like-particles (VLP).

Benefits:

The Sartobind S adsorber speeds up the production process by high flow rate and opens new opportunities for the purification of therapeutic proteins and vaccines.

  • High speed host cell protein removal up to 30 bed volumes/ min
  • Aggregate removal

Easy to use:

  • Plug and play devices from 0.08 ml to 5 l
  • Can be used like a filter
  • Flow rate up to 30 bed volumes/min
  • Disposable or re-usable

Applications

  • Application
    Polishing

Compliance Information

  • Biological Reactivity
    All materials of this filter element meet the requirements of the current USP Biological Reactivity tests <88> for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).

Connections (Physical)

  • Connector(s)
    Female Luer lock

Dimensions

  • Bed Height
    4 mm
  • Dimensions
    37 x 31 mm
  • Membrane Area
    36.4 cm²

Features

  • Reusable
    Yes

Materials of Construction

  • Housing Material
    Polypropylene (PP)
  • Materials of Construction
    • Polypropylene
    • Polyester
  • Membrane Material
    Stabilized reinforced cellulose

Operating Conditions

  • Maximum Operating Pressure
    0.4 MPa
  • Maximum Venting Pressure
    0.5 bar, 0.05 MPa, 7 psi
  • Recommended Flow Rate
    20 mL/min
  • pH Stability
    pH 3 – 14 (short term), pH 4 – 13 (long term)

Physicochemical Information

  • Bed Volume
    1 mL
  • Chemical Compatibility
    Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
  • Ligand
    Sulfonic acid
  • Ligand Density
    2 – 5 µeq/cm²
  • Pore Size
    3 – 5 µm
  • Reference Protein
    Lysozyme
  • Thermal Stability
    Sartobind capsules with ion exchange membranes can be autoclaved at 121 °C for 30 min. We recommend one autoclaving cycle only.
  • Typical Dynamic Binding Capacity 10% per unit
    25 mg
  • Void Volume
    3.5 mL

Product Information

  • Brand
    Sartobind® S
  • Membrane Adsorber Format
    Capsules
  • Membrane Type
    Strong cation exchanger
  • Pack Size
    4
  • Type
    Membrane adsorber
  • What you receive
    • 4 capsules
    • 2 adapters Luer male to UNF 10-32 female
    • 1 operating instruction
    • 1 certificate
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