Sartobind® S Cassette

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Sartobind® S Cassette Sartobind® S Cassette Sartobind® S Cassette
 

Sartobind® S membrane adsorber units combine the advantages of convective media and ion exchange chromatography for rapid and easy contaminant removal or capture of virus and virus like particles.

The cassette design eliminates the 5 L size limitation for membrane adsorbers and offers simple pod-like modular system up to 100 L membrane volume.

Bed Volume
Item No.: 
98IEXS42D-L
Availability: 

*Custom/bulk order quotes are provided within 72 hours of request.

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Sartobind® S membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Sulfonic acid ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.

Applications:

The S membrane adsorber is successfully used in FDA-approved drug manufacture to remove host cell proteins at high flow rates. As a cation exchanger it displays not only aggregate removal capabilities but typically at least ten-fold higher binding capacity for viruses and virus-like-particles (VLP).

Benefits:

The Sartobind S adsorber speeds up the production process by high flow rate and opens new opportunities for the purification of therapeutic proteins and vaccines.

  • High speed host cell protein removal up to 30 bed volumes/ min
  • Aggregate removal

Easy to use:

  • Plug and play devices from 0.08 ml to 5 l
  • Can be used like a filter
  • Flow rate up to 30 bed volumes/min
  • Disposable or re-usable

Applications

  • Application
    Polishing

Compliance Information

  • Biological Reactivity
    All materials of this filter element meet the requirements of the current USP Biological Reactivity tests <88> for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).

Connections (Physical)

  • Connector(s)
    Sanitary 1" – 1.5" via manifold

Dimensions

  • Bed Height
    4 mm
  • Dimensions WxDxH
    634 × 49 × 387 mm
  • Membrane Area
    2.9 m²

Features

  • Reusable
    Yes

Materials of Construction

  • Housing Material
    Acrylonitrile butadiene styrene (ABS)
  • Materials of Construction
    Polyester
  • Membrane Material
    Stabilized reinforced cellulose

Operating Conditions

  • Maximum Operating Pressure
    0.2 MPa
  • Maximum Venting Pressure
    0.5 bar, 0.05 MPa, 7 psi
  • Recommended Flow Rate
    16 L/min
  • pH Stability
    pH 3 – 14 (short term), pH 4 – 13 (long term)

Physicochemical Information

  • Bed Volume
    0.8 L
  • Chemical Compatibility
    Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
  • Ligand
    Sulfonic acid
  • Ligand Density
    2 – 5 µeq/cm²
  • Pore Size
    3 – 5 µm
  • Reference Protein
    Lysozyme
  • Thermal Stability
    Sartobind cassettes with ion exchange membranes cannot be autoclaved, but they can be gamma irradiated.
  • Typical Dynamic Binding Capacity 10% per unit
    23.2 g
  • Void Volume
    2.5 L

Product Information

  • Brand
    Sartobind® S
  • Membrane Adsorber Format
    Cassettes
  • Membrane Type
    Strong cation exchanger
  • Pack Size
    1
  • Type
    Membrane adsorber
  • What you receive
    • 1 cassette
    • 1 operating instruction
    • 1 certificate
  • Manifold Set for Sartoclear® Depth Filters and Sartobind® Membrane Adsorbers
    Manifold Set for Sartoclear® Depth Filters and Sartobind® Membrane Adsorbers
    Item no.
    29Z-S00001

    The manifold set contains the inlet and outlet adapter plates for Sartoclear® Depth Filters as well as Sartobind® membrane adsorbers cassettes.

  • Process Filter Holder — For Sartoclear® Depth Filters and Sartobind® Membrane Adsorbers
    Process Filter Holder — For Sartoclear® Depth Filters and Sartobind® Membrane Adsorbers
    Item no.
    2ZGL--0006

    Filter Holders are hydraulic clamping systems especially designed for the use of modular Sartoclear® Depth Filter cassettes and Sartobind® membrane chromatography cassettes. The holders are available in three standard formats for pilot scale and commercial manufacturing.

  • Pilot Filter Holder — For Sartoclear® Depth Filters and Sartobind® Membrane Adsorbers
    Pilot Filter Holder — For Sartoclear® Depth Filters and Sartobind® Membrane Adsorbers
    Item no.
    2ZGL--0005

    Filter Holders are hydraulic clamping systems especially designed for the use of modular Sartoclear® Depth Filter cassettes and Sartobind® membrane chromatography cassettes. The holders are available in three standard formats for pilot scale and commercial manufacturing.

  • Double Process Filter Holder — For Sartoclear® Depth Filters and Sartobind® Membrane Adsorbers
    Double Process Filter Holder — For Sartoclear® Depth Filters and Sartobind® Membrane Adsorbers
    Item no.
    2ZGL--0007

    Filter Holders are hydraulic clamping systems especially designed for the use of modular Sartoclear® Depth Filter cassettes and Sartobind® membrane chromatography cassettes. The holders are available in three standard formats for pilot scale and commercial manufacturing.