CIMac r-Protein L 0.1 mL Analytical Column (1.3 µm)

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CIMac r-Protein L 0.1 mL Analytical Column (1.3 µm)
 

The CIMac r-Protein L Analytical Columns are designed for rapid and efficient HPLC monitoring and quantitation of a wide range of antibodies and antibody fragments, including Fabs, single-chain variable fragments (scFv), and domain antibodies (Dabs). This makes them ideal for process analytical technology (PAT). Utilizing recombinant Protein L from E. coli, these columns offer the unique ability to bind to kappa light chains of immunoglobulins, regardless of heavy chain subclass, providing an advantage over proteins A and G.

Notice: CIMac r-Protein L is a non-standard product. Provided on request.

Item No.: 
110.1021-1.3
*Custom/bulk order quotes are provided within 72 hours of request.
CIMac r-Protein L 0.1 mL Analytical Column (1.3 µm)
CIMac r-Protein L 0.1 mL Analytical Column (1.3 µm)

The CIMac r-Protein L Analytical Columns are designed for rapid and efficient HPLC monitoring and quantitation of a wide range of antibodies and antibody fragments, including Fabs, single-chain variable fragments (scFv), and domain antibodies (Dabs). This makes them ideal for process analytical technology (PAT). Utilizing recombinant Protein L from E. coli, these columns offer the unique ability to bind to kappa light chains of immunoglobulins, regardless of heavy chain subclass, providing an advantage over proteins A and G.

Notice: CIMac r-Protein L is a non-standard product. Provided on request.

Item No.:
110.1021-1.3

Overview

Specifications

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CIMac Analytical Columns are short-bed high-performance monolithic columns offering all the advantages of CIM® monolithic technology. Their small volume and short column length allow the operation at high volumetric flow rates, enabling them to receive the information about the product quantity and purity in just a few minutes. Hence, the CIMac Analytical Columns can be effectively used for the in-process and final control of various samples from different purification process steps.

The CIMac r-Protein L Analytical Columns are designed for rapid and efficient HPLC monitoring and quantitation of a wide range of antibodies and antibody fragments, including Fabs, single-chain variable fragments (scFv), and domain antibodies (Dabs). This makes them ideal for process analytical technology (PAT). Utilizing recombinant Protein L from E. coli, these columns offer the unique ability to bind to kappa light chains of immunoglobulins, regardless of heavy chain subclass, providing an advantage over proteins A and G.


Key Features:

  • Efficient purification of a wide range of antibodies and antibody fragments
  • Binds to kappa light chains, offering species-independent binding
  • Advantageous over proteins A and G due to its broad binding capabilities

Notice: CIMac r-Protein L is a non-standard product. Provided on request.

Applications

  • Application
    Analytical Columns

Compliance Information

  • GMP Compliance
    non-cGMP

Connections (Physical)

  • Connector(s)
    10-32 UNF coned port, 0.0625" OD tubing connection

Dimensions

  • Channel Size
    1.3 µm
  • Diameter
    5.2 mm

Features

  • Reusable
    Yes

General Specifications

  • Flow Rate
    0.2 – 3 mL/min | 1 – 15 cm/min | 2 – 30 CV/min

Materials of Construction

  • Materials of Construction
    Poly(glycidyl methacrylate -co- ethylene dimethacrylate)

Operating Conditions

  • Maximum Operating Pressure
    15 MPa | 150 bar | 2175 psi
  • Operating Pressure
    4.95 mm
  • Recommended Operating Temperature
    4 °C (39 °F) to 40 °C (104 °F)
  • pH Stability
    Working range 2–10, cleaning in place 2–12.5

Physicochemical Information

  • Bed Volume
    0.1 mL
  • Ligand
    r-Protein L (affinity; recombinant protein L produced from E. coli coupled to CDI-preactivated support)

Product Information

  • Brand
    CIMac™
  • Package Type
    Individually Packed

Volume

  • Volume
    0.1 mL