HEA HyperCel is a mixed-mode resin with a less hydrophobic hexylamine ligand allowing protein binding at a moderate salt concentration under neutral pH.

Pack Volume
Price (USD):
$187.00
Item No.: 
20250-026

*Custom/bulk order quotes are provided within 72 hours of request.

HEA HyperCel resin is an industry-scalable chromatography resin designed for protein capture and impurity removal in a biopharmaceutical environment. Operating on a “mixed-mode” mechanism, with a hexylamine ligand, its behavior is based on a combination of electrostatic and hydrophobic interactions of the proteins with the ligands. HEA HyperCel resin provides unique selectivities, different from those given by ion exchange or conventional HIC (hydrophobic interaction chromatography).

Features and Benefits

- High mechanical and chemical stability
- Suitable for large-scale chromatography in a biopharmaceutical environment
- Cross-linked cellulose base matrix


Applications

- Protein purification at low ionic strength by direct hydrophobic capture
- Separation of challenging mixtures, e.g. protein isoforms or proteins with very close pIs
- Orthogonal separation mechanism to ion exchange or HIC

Applications

  • Application
    Preparative protein purification  

Compliance Information

  • Quality Standards
    • CoA  
    • RSF  

Dimensions

  • Bead Size
    80 - 100 µm  

General Specifications

  • Flow Rate
    100-600cm/h  
  • Resin Format
    Bulk resin  

Materials of Construction

  • Base Matrix
    Rigid cellulose beads  

Operating Conditions

  • Operating Pressure
    < 3 barg (44psi)  
  • pH Stability
    1 to 14 (short term), 2 to 12 (long term)  

Physicochemical Information

  • Ligand
    Hexylamine  
  • Reference Protein
    Bovine serum albumin (BSA)  
  • Typical Dynamic Binding Capacity 10% per mL
    40-60 mg/mL BSA  

Product Information

  • Brand
    HEA HyperCel  
  • Pack Size
    1  
  • Pack Volume
    25 mL  
  • Resin Delivery Condition
    1M NaCl with 20% EtOH  
  • Resin Type
    Mixed-mode anion exchanger  
  • What you receive
    1 bottle resin, instructions  

Storage Conditions

  • Storage Conditions
    20% EtOH/1 M NaCl