Sartobind® Q Capsule 200 mL with 4 mm bed height
Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.
- Item No.:
- 96IEXQ42D1GSS
*Custom/bulk order quotes are provided within 72 hours of request.
Sartobind® Q membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Quaternary ammonium ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.
Applications virus and VLP capture:
As size exclusion effects are negligible, they are suited for purification of viruses and display one order of magnitude higher dynamic binding capacity compared to resin. Viruses such as adeno- or lentiviruses are captured at high flow rates. The material allows also >100 cycles of re-use without loss of binding capacity.
Benefits capture:
- High speed purification at 5 - 30 bed volumes per minute
- No size exclusion effects for large proteins an viruses / VLPs
- >10fold higher binding capacities compared to conventional resins
Applications flow-through polishing:
Sartobind Q is the perfect tool for the flow-through polishing of valuable proteins such as monoclonal antibodies. The bed volumes can be kept sufficiently small during the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins from such pharmaceutical proteins.
Benefits flow-through polishing:
- Virus clearance > 6 log
- DNA below detection limit
- Host cell protein removal > 99 %
- Endotoxin removal > 5 log
- Save 80 % of column costs
Easy to use:
- Plug and play devices from 0.08 mL to 5 L
- Can be used like a filter
- Flow rate up to 30 bed volumes/min
- Re-usable or disposable
Applications
-
ApplicationPolishing
Compliance Information
-
Biological ReactivityAll materials of this filter element meet the requirements of the current USP Biological Reactivity tests <88> for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).
Connections (Physical)
-
Connector(s)Inlet: 1 ½" Sanitary | Outlet: 1 ½" Sanitary
Dimensions
-
Bed Height4 mm
-
Dimensions WxDxH10 × 35 cm
-
Membrane Area0.73 m²
Features
-
ReusableYes
Materials of Construction
-
Housing MaterialPolypropylene (PP)
-
Materials of Construction
-
Polypropylene
- Polyester
-
Polypropylene
-
Membrane MaterialStabilized reinforced cellulose
Operating Conditions
-
Maximum Operating Pressure0.4 MPa
-
Maximum Venting Pressure0.5 bar, 0.05 MPa, 7 psi
-
Recommended Flow Rate4 L/min
-
pH StabilitypH 2 – 14 (short term), pH 2 – 12 (long term)
Physicochemical Information
-
Bed Volume200 mL
-
LigandQuaternary ammonium
-
Ligand Density2 – 5 µeq/cm²
-
Pore Size3 – 5 µm
-
Reference ProteinBovine serum albumin (BSA)
-
Thermal StabilitySartobind capsules with ion exchange membranes can be autoclaved at 121 °C for 30 min. We recommend one autoclaving cycle only.
-
Typical Dynamic Binding Capacity 10% per unit5.8 g
-
Void Volume540 mL
Product Information
-
BrandSartobind® Q
-
Membrane Adsorber FormatCapsules
-
Membrane TypeStrong anion exchange membrane
-
Pack Size1
-
TypeMembrane adsorber
-
What you receive
-
1 capsule
-
1 operating instruction
- 1 certificate
-
1 capsule
Sterility/Purity
-
Sterilization MethodAutoclavable