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HyperCel Star AX is a salt-tolerant anion exchanger with a primary amine as functional group. It can easily be integrated into a purification workflow without feed stream manipulation.

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HyperCel STAR AX
HyperCel STAR AX

HyperCel Star AX is a salt-tolerant anion exchanger with a primary amine as functional group. It can easily be integrated into a purification workflow without feed stream manipulation.

Item No.:
M_HyperCel_STAR_AX

Overview

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HyperCel STAR AX is an industry-scalable anion exchange chromatography resin designed for high productivity protein capture at moderate or higher salt conductivity (2 to 15 mS/cm), typical of undiluted biological feedstocks (e.g. mammalian cell culture supernatants, E. coli feedstock, plasma, etc.).

Features and Benefits

  • High dynamic binding capacity (DBC) at short residence time (2 minutes or lower)
  • Direct capture of protein from undiluted feedstock at moderate or high conductivity
  • Excellent flow rate properties for fast feedstock processing
  • Distinctive selectivity, consistent in a broad conductivity range (2 – 15 mS/cm)
  • Enhanced process economics
  • Manufactured at large scale and to meet the demands of commercial users and regulatory authorities

Applications

  • Direct capture of recombinant proteins, mono- and poly-clonal antibodies, plasma derivatives
  • Direct Capture of Albumin from Undiluted Plasma
  • Early Removal of CHOPs before Protein A Capture of a Monoclonal Antibody (mAb)

Compliance Information

  • Quality Standards
    • CoA
    • RSF (upon request)

Dimensions

  • Bead Size
    60 - 90 µm

Materials of Construction

  • Base Matrix
    Rigid cellulose beads

Operating Conditions

  • Operating Pressure
    < 3 barg (44psi)
  • pH Stability
    1 to 14 (short term), 2 to 12 (long term)

Physicochemical Information

  • Ligand
    Primary amine (PA)
  • Reference Protein
    Bovine serum albumin (BSA)
  • Typical Dynamic Binding Capacity 10% per mL
    > 100 mg/mL BSA at pH 7.5 to 8.0 and conductivity to 15 mS/cm

Product Information

  • Brand
    HyperCel STAR AX
  • Resin Delivery Condition
    1M NaCl with 20% EtOH
  • Resin Type
    Ion Exchange

Storage Conditions

  • Storage Conditions
    20% EtOH/1M NaCl