Sartobind® Convec D Mini 20 mL with 8 mm bed height

The Sartobind® Convec D product family represents a cutting-edge solution in the realm of anion exchange chromatography, specifically designed to deliver high recovery rates of infectious lentivirus particles, ensuring efficient purification processes across various scales. Below, we provide an in-depth overview of the main formats, applications, materials, and advantages of the Sartobind® Convec D product family.

Applications:

• Virus Capture: Ideal for Lentivirus
• Gene Therapy Manufacturing: Supports the purification of Extracellular Vehicles (EVs).

Formats:

The Sartobind^® Convec D product family is available in multiple formats, catering to different production requirements:

Nano (3 mL):

• Ideal for small-scale research and process development.
• Compact design with Luer female connectors for easy integration.

Mini (20 mL):

• Suitable for medium-scale production and pilot studies.
• Intermediate sizes offering a balance between capacity and footprint.

Materials:

The Sartobind^® Convec D product family is constructed from high-quality materials to ensure durability and performance:

• Membrane Material: Stabilized reinforced cellulose, providing a stable matrix for viral capture.
• Ligand Chemistry: Diethyl amino moiety (-NH(C₂H₅)₂) for weak anion exchange, optimized for bind and elute function.
• Capsule Components: Polypropylene made outer cage, inner core, end caps, and capsule housing are designed to withstand operational pressures and maintain integrity.
• Gamma-Irradiatable Format: Available for enhanced sterility and reduced contamination risks.

Advantages:

The Sartobind^® Convec D product family offers several advantages, making it a preferred choice for viral vector purification:

• High Recovery Rates: Achieves over 60% recovery of infectious particles, maximizing yield.
• High Selectivity and Purity: Reduces non-specific binding, ensuring high purity and yield of target molecules.
• Short Residence Times: Enables rapid processing, increasing throughput and productivity.
• Linear Scalability: Maintains consistent performance across different scales, from laboratory to manufacturing scale
• Aseptic Processing: Available in gamma-irradiated versions to support closed and aseptic processing.
• Simplified 'plug and play': Device formats with choice of tubings and connectors.