Sartobind® Convec SC Nano 3 mL with 8 mm bed height

Sartobind^® Convec SC Membrane Chromatography

The Sartobind^® Convec SC product family is a cutting-edge solution in membrane chromatography, designed to meet the diverse needs of biopharmaceutical purification processes. This family of products is engineered to provide high productivity, scalability, and safety in the purification of viruses, viral-like particles (VLPs) such as Influenza, Vaccinia, Rabies, Japanese encephalitis, and large proteins, making it an ideal choice for modern bioprocessing applications.

Applications:

• Virus Capture: Efficiently captures viruses and VLPs such as influenza, Vaccinia, Rabies, Encephalitis, HSV
• Viral and microbial antigens: Herpes simplex gA and gB glycoprotein subunits Hepatitis B surface antigen, Filamentous hemagglutinin from B. pertussis, Leukocytosis-promoting factor hemagglutinin
• Proteins: Lysozyme AntithrombinIII, b-Lipoprotein, FactorIX
• Gene Therapy Manufacturing: Supports the purification of viral vectors like AAVs.

Formats:

The Sartobind® Convec SC product family is available in multiple formats, catering to different production requirements:

Nano (3 mL):

• Ideal for small-scale research and process development.
• Compact design with Luer female connectors for easy integration.

Materials:

• Membrane Material: Stabilized reinforced cellulose, providing a robust and stable matrix for viral capture.
• Ligand Chemistry: OSO₃ (Sulfated cellulose), Synthetic ligand, and Animal-origin-free ligand ensure safety and compliance with regulatory standards.
• Capsule Components: Polypropylene made outer cage, inner core, end caps, and capsule housing are designed to withstand operational pressures and maintain integrity.
• Gamma-Irradiatable Format: Available for enhanced sterility and reduced contamination risks.
• Animal-Free Synthetic Ligands: Ensures compliance with regulatory standards and safety in biopharmaceutical applications.

Advantages:

• High Dynamic Binding Capacity (DBC): Offers superior binding capacity for large biomolecules, enhancing process efficiency.
• Short Residence Times: Enables rapid processing, increasing throughput and productivity.
• High Selectivity and Purity: Reduces non-specific binding, ensuring high purity and yield of target molecules.
• Linear Scalability: Maintains consistent performance across different scales, from laboratory to manufacturing scale.
• Versatile Compatibility: Accommodates a wide range of molecule sizes and types, making it suitable for various bioprocessing needs.
• Aseptic Processing: Available in gamma-irradiated versions to support closed and aseptic processing.
• Simplified 'plug and play': Device formats with choice of tubings and connectors.

Product Features and Benefits:

• Pseudo-Affinity Binding Mechanism: Provides selective capture of viruses and large proteins, mimicking natural binding interactions.
• Enhanced Recovery Rates: Achieves high recovery rates for various viruses and proteins, ensuring efficient purification.
• Improved Process Efficiency: Shorter residence times and higher flow rates increase throughput and reduce processing time.
• Comprehensive Product Portfolio: Offers a complete range of products to support diverse purification needs in biopharmaceutical manufacturing.