Sartocube® Q Cassette | Hydrosart® | 30kDa mAb | 3.09m² | Q-Screen

TFF Cassettes for mAb Filtration

Sartocon® Q Hydrosart® 30 kDa mAb features a stabilized cellulose membrane and Q‑Screen channel in a self‑sealing TFF cassette. It supports buffer exchange, volume reduction and target concentration steps for monoclonal antibodies with efficient mass transfer and straightforward scale‑up.

Format and Design

• Self‑sealing cassette format eliminates separate gaskets and simplifies setup.
• Enlarged feed and retentate ports help reduce pressure drop across the device.
• Silicone sealing compound is formulated for low extractables.
• Designed to integrate into TFF filter setups and ultrafiltration cassette platforms.

Membrane and Screen

• Hydrosart® stabilized cellulose membrane with a new 30 kDa molecular‑weight cutoff specifically designed for mAb processing.
• Hydrophilic, non‑protein‑binding surface supports yield and limits nonspecific adsorption.
• Low fouling tendency supports consistent operation.
• Consistent performance maintained even after multiple NaOH cleanings, ensuring reliable repeated use.
• The advanced new screen type, called Q-Screen, enables higher final antibody concentrations.
• High permeate flow enables efficient processing at both medium and high concentrations.
• This medium channel promotes mass transfer even at low feed flow for efficient throughput.

Applications

• Concentration of monoclonal antibody solutions prior to formulation.
• Ultrafiltration and diafiltration for buffer exchange and volume reduction.
• TFF process development, scale‑up, and manufacturing runs.

Advantages at a Glance

• New designed 30 kDa cutoff for consistent separation performance.
• Scalable platform from development to production with reproducible retention at a high level.
• Processing of medium and high viscocities with high flow of permeate.
• Stable flows after NaOH cleaning.
• Broad pH compatibility aligned with common bioprocess requirements.
• Simplified handling and cleaning to support efficient turnaround.