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Tangential Flow Filtration (TFF) (1106)
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Tangential Flow Filtration (TFF) SystemsProduct FamilyTFF Systems - Process Solutions for Ultrafiltration and Diafiltration
Sartorius offers flexible tangential flow filtration (TFF) systems for process development and clinical trials up to commercial production batches.
The TFF portfolio can flex to accommodate individual requirements, with a range of options that includes cost-efficient multi-use systems or closed systems with single-use flow kits for bioburden reduced processing.
Key Features
Benchtop to production scale from 100 mL to 200 L
Working membrane sizes from 10 cm² to 10 m²
Single-use and multi-use
Highly- to fully automated
Compliancy to cGMP available
Modular standard systems allow shorter lead times -
Sartocon® and Sartocube® | TFF Ultrafiltration | CassettesProduct Family
Membrane Materials: Hydrosart® or Polyethersulfone
Effective Filtration Areas: 0.02m² - 3.5m²
Cut-Offs: 1 - 300 kDa
Screen Types: E-Screen or ECO Screen -
Sartocon® and Sartocube® | TFF Microfiltration | CassettesProduct Family
Membrane Materials: Hydrosart® or Polyethersulfone
Effective Filtration Areas: 0.02m² - 3m²
Pore Sizes: 0.1µm | 0.2µm | 0.45µm
Screen Types: Open Channes | Wide Spacer -
Ambr® CrossflowProduct FamilyStudy factors for manufacturability
Collect important information about the behaviour of the molecules in downstream processing already in an early stage
Automated, parallel trials
Up to 16 channels can be managed by one control station
Lowest process volumes
Small scale screening with 10 cm² membrane area | 5 mL recirculation volume
Flexibility of two different process scales
Mid-scale screening is also possible with Sartocon® Slice 50 which has 50 cm² membrane area
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Sartoflow® Single-Use Flow KitsProduct FamilyKey Features & Benefits
Reduces preparation time
Decreases the need for cleaning validation and the risk of cross-contamination between different molecule productions
Enabels faster change-over between different products
More efficient and productive system use
Increased facility flexibility
Increased productivity per sqm manufacturing space -
Sartocon® and Sartocube® | TFF Ultrafiltration | Self-ContainedProduct Family
Self-Contained Unit (SCU): Pre-flushed, sterile and ready to use
Cut-Offs: 10 - 300 kDa
Effective Filtration Areas: 0.14 - 14m²
Membrane Material: Hydrosart® or Polyethersulfone
Channel Design: ECO
Connectors: AseptiQuik®
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Tangential Flow Filtration (TFF) Filter HoldersProduct FamilyKey Features of the TFF Filter Holders
Self-draining and self-venting thanks to vertical positioning
Large retentate channels for low pressure drop
Easy installation
Low hold-up volume
Monolithic design
All ports located on the product plate -
Hollow Fiber TFFProduct FamilyExperience ultra- and microfiltration performance with our Hollow Fiber TFF modules. Designed to balance between fiber stability and integrity as well as performance for optimal efficiency, these modules are ideal for a wide range of bioprocessing and pharmaceutical applications.
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Item no.Pore Size0.45µmSealing CompoundSilicone White (High chemical resistance)
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Item no.Cassette CapacitySartocon® Cassettes: ≤ 10Mirror InvertedNoConnectionsJIS-GItem no.Cassette CapacitySartocon® Cassettes: ≤ 10Mirror InvertedNoConnectionsJIS-GItem no.Cassette CapacitySartocon® Cassettes: ≤ 10Mirror InvertedYesConnectionsZollItem no.Cassette CapacitySartocon® Cassettes: ≤ 10Mirror InvertedNoConnectionsISO
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Sartocon®
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Silicone Grey
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Slice Cassettes
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< 0.18 EU/mL as determined by the LAL test
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