CIMmultus® QA 400 mL cGMP Compliant Monolithic Column (6 μm)

CIMmultus^® Monoliths are reusable chromatography devices for scalable high-resolution purification of complex biological samples. Inside the custom designed housing is a single piece stationary phase with homogeneous channel size and surface chemistry. This stationary phase is designed to simplify method transfer from development into production.

CIMmultus^® columns can be used as single-use disposable or multi-use columns. They are available in a variety of volume ranges – from 1mL for screening and method development purposes up to 40L for industrial manufacturing.

CIMmultus^® QA is a high-performance ion exchange column primarily intended for fast and efficient purification of biomolecules such as viruses, adeno-associated viruses (AAV), and virus-like particles (VLP) through their ionic interaction with the monolith.

QA (quaternary amine) features:

• Strong anion exchanger
• Working range, pH 2–13
• Binds molecules with a predominantly negative charge, repels molecules with a predominantly positive charge
• Use for capture, intermediate, or polishing steps in either bind-elute or flow-through mode
• High capacity for virus particles (AAV), IgM, exosomes
• High efficiency removal of endotoxin and DNA removal
• Outstanding for preparative applications or analytical fingerprinting of process samples
• Sanitizable with 1 M NaOH

Benefits:

• Very fast processes by convective mass transport – resolution independent of flow
• Ready to use columns
• High-capacity for large molecules due to fully accessible void volume in the channels
• Laminar flow minimizes shear stress resulting in high yields