Proteinase K to digest contaminating proteins and improve the extraction of nucleic acids from various biological samples. The Microsart® AMP Extraction Kit f is designed for highly efficient extraction of mycoplasma DNA from standard samples, like cell culture supernatants containing up to 106 cells. However, other samples matrices like cell pellets, serum, or fermentation products may contain proteins at a concentration higher than 10 mg/ml. These samples may require an additional treatment with Proteinase K to increase the overall DNA yield and reach highest sensitivity