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Process Automation & Process Analytical Technologies (PAT) (14)
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BioPAT® ViamassProduct Family
Automated Biomass Measurement Using BioPAT® Viamass
BioPAT® Viamasss is a system for measuring viable biomass in cell culture processes. Unlike known reference methods, this system is completely integrated into single-use bioreactors. It determines the biomass directly in line and reducing the need for manual sampling. Integrated into the bioreactor’s DCU and Biobrain® control system, BioPAT® Viamass permits automatic monitoring and control of viable biomass.
Reduces the need for manual sampling
Real-time measurement of and feedback on viable biomass
Ensures batch-to-batch consistency
Eliminates operator influence that occurs in manual biomass measurements -
Biobrain® SuperviseProduct FamilyBiobrain ® Supervise enables a new standard in bioprocess data management and automation. Its capabilities for data acquisition, process trend monitoring, and recipe management and control make it an ideal tool for all up and down stream processes, no matter if you prefer single-use or reusable systems. Whether you want a non-qualified system for your PD facility or a qualified system that can meet your 21 CFR part 11 or Annex 11 needs we have deployment option sized for you.
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BioPAT® XgasProduct Family
BioPAT® Xgas – Online Off-Gas Analysis for Monitoring and Controlling Bioprocesses
The BioPAT® Xgas monitors exhaust gas from bioprocesses in real time. It is a dual oxygen–carbon dioxide sensor featuring automatic compensation for humidity and pressure. Oxygen concentration can be measured in a range of 1–50%, and carbon dioxide concentration in a range of 0–10%.
Simultaneous determination of O₂ and CO₂ with a single sensor
Seamless integration into Biostat® and Biobrain® Supervise / BioPAT® tools*
Monitoring of metabolic processes
Tool for process and yield optimization
Compact design for flexible use
Automatic moisture and pressure compensation -
BioPAT® FundaluxProduct FamilyBioPAT®Fundalux is an absorption-based photometric probe that uses light from 840nm to 910nm to measure the turbidity in bioreactors and fermenters. A precisely defined and constant LED light beam passes through the process medium from either side of the gap on the probe’s shaft.
Designed for use in R&D, as well as in pilot- and production-scale
Monitoring cell growth in bacterial fermentation and mammalian cell cultures.
Online triggering of control loops for advanced automated fermentation.
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Biobrain® Automation PlatformProduct FamilyBiobrain® is Sartorius automation platform designed to support a range of bioprocessing applications and workflows. It provides native connectivity to Biobrain® Supervise and can also integrate with third-party systems, including data historians, SCADA, and DCS platforms, enabling data acquisition and higher-level process integration.
The platform supports both conventional batch operations and advanced process strategies. Its functionality includes recipe-based process control, operator guidance for setup and execution activities, and support for integrated process monitoring and control capabilities.
Recipes can be developed through Sartorius services or created using the Biobrain® Recipe Editor software. Organizations can expand their capabilities over time by upgrading to Biobrain® Supervise, adding enhanced data management, cross-process analysis, visualization, and remote notification features.
Biobrain® is developed with a long-term lifecycle approach, enabling continuous enhancement of functionality, connectivity, and security. This supports evolving customer requirements and facilitates the adoption of future digital biomanufacturing and BioPharma 4.0 initiatives.
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BioPAT® Pinch ValveProduct FamilyThe BioPAT® Pinch Valve is an innovative valve solution for flow rate control and open | close applications. It consists of an electrical drive, a valve body and an installation set. Tubing can easily be installed and secured in the valve, without have to deal with loose parts. The BioPAT® Pinch Valve is available in three sizes A, B and C, achieving more flexibility for tubing sizes through the different installation sets available.
Re-opening mechanism
Non-product contacting
Robust and accurate electrical drive
Gentle on the tubing
Available for tube diameters ranging from 1/8" to 1" IDThe Valve Body comes together with the necessary installation set.
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BioPAT® PressureProduct FamilyThe in-line pressure sensors of the BioPAT ® Pressure family provide the right fit for all scales of your bioprocess. The new design allows a high degree of flexibility suitable for more applications in biomanufacturing and includes several improvements, resulting in better longevity, handling and accuracy.
Non-invasive pressure measurement
Available for tube diameters ranging from ¼” to 1” ID
Compatible with a wide range of fluid properties
Automatic temperature compensation
New fixing mechanism integrated in the single-use pressure pipe -
BioPAT® TraceProduct FamilyOnline Measurement of Multiple Parameters From 1 to 4 Vessels. The control of nutrients and metabolites starts by monitoring the parameter concentration and its rate of change. Once known, then an actuator (e.g. feed pump) can affect a change and bring the parameter to the desired set-point. BioPAT® Trace and BioPAT® Multi Trace enables this control to be automated without the need for operator intervention during the bioprocess. Real-time online monitoring of bioprocesses parameters.
Glucose and lactate
Methanol or ethanol
Enable automated parameter feed | bleed control capability
Single-use sensor and fluidic element
Compact, space-saving design
Room temperature stable biosensors
Wide linear measuring range -
BioPAT® FlowProduct FamilyBioPAT® Flow - Accurate and Flexible Flow Measurement from Process Development to Commercial Production
Non-invasive, ultrasonic flow measurement
World’s most accurate single-use ultrasonic flow clamp-on
Available for tube diameters ranging from ¼“ to 1“ ID.
Independent of fluid viscosity and system pressure
Temperature compensation from 4 – 37 °C
The integration of the flow sensor is fast and easy. The flow pipes can be integrated into any single-use tube assembly without introducing bends or changing the inner diameter. The clamp-on transmitter is then simply fixed around the pipe and the measurement can take place.
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BioPAT® Spectro UVProduct Family
Unlocking the Potential of Single-Use Inline UV Absorbance
Monitoring for Flexibility and Performance
The BioPAT® Spectro UV family offers a new perspective on UV light absorbance measurements in single-use biomanufacturing processes. Unlike most of the alternatives on the market, which restrict the absorbance values to discrete wavelengths, BioPAT® Spectro UV makes the entire light absorbance spectrum between 190 nm and 390 nm continuously available.
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BioPAT® Low FlowProduct FamilyThe BioPAT® Low Flow sensor is an ultrasonic Clamp-on sensor with integrated converter for high precision and robust non-invasive flow measurement. The sensor is specifically designed to measure with high precision within its entire specified flow range (3% - 30% Qmax). Inside the flow clamp-on three pairs of piezoelectric sensors function both as a source and a detector for ultrasound waves. The BioPAT® Low Flow ultrasonic sensors are the world’s only flow meter clamp-ons that use a single-use flow pipe instead of measuring directly on the tube. This innovation comes with several advantages.
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Biobrain® Operate powered by TulipProduct FamilyBiobrain® Operate is powered by Tulip—a leading no-code frontline operations platform. This integration empowers users to build, modify, and deploy digital workflows without traditional software development, accelerating innovation on the shop floor and enhancing agility in production environments.
This subscription provides access to a validated, compliant-ready version of the Tulip Frontline Operations Platform, specifically designed for use in regulated environments such as pharmaceuticals, biotechnology, and medical devices.