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Tangential Flow Filtration (TFF)

Most used filters

Brand

Ambr® CF Filter (11)
Ambr® crossflow (11)
Sartocon® (144)
Sartocon® 2 plus (9)
Sartocon® Slice (2)
Sartocon® Slice 200 (2)
Sartocube® (40)
Sartoflow® (42)
Sartoflow® 10 (1)
Sartoflow® 20 (1)

Cassette Format

ambr® CF filter (11)
Sartocon Cassettes (52)
Sartocon® SCU (24)
Sartocube Cassettes (26)
Sartocube® SCU (25)
Slice 200 Cassettes (27)
Slice 50 Cassettes (21)
Slice Cassettes (54)
Standard Cassettes (2)

Filtration Area

MWCO

Albumin retentive (4)
1 kD (2)
1 kDa (3)
2 kD (2)
2 kDa (4)
3 kD (1)
3kD (82)
5 kD (4)
5 kDa (8)
5kD (83)
8 kD (1)
8 kDa (3)
10 kD (6)
10 kDa (28)
10kD (84)
30 kD (5)
30 kDa (28)
30 kDa mAb (4)
30kD (84)
50 kD (2)
50 kDa (4)
50kD (83)
100 kD (4)
100 kDa (30)
100kD (84)
300 kD (5)
300 kDa (28)
300kD (84)
500kD (84)
750kD (84)

Membrane Material

Hydrosart® (96)
mPES (868)
Polyethersulfone (PES) (91)

Sealing Compound

Not Applicable (22)
Silicone Grey (50)
Silicone White (High chemical resistance) (106)

Filter by product attributes

Additional Product Specifications

Conductivity sensor (1)
Feet: Polyethylene (PE) (1)
Flow sensor (1)
Holder Hold-up volume in permeate channel: < 2 ml (1)
Holder Hold-up volume in retentate channel: < 2 ml (1)
Integrated 5-piston single-use diaphragm pump head with integrated overpressure protection at 4 bar (18 L/min) (1)
Nuts for tie rods: Bronze (2)
Pressure sensor (2)
Software: Biobrain® Recipe tool (1)
Temperature sensor (1)
UV sensor (1)

Application

ADC (1)
Antibody (23)
Antibody Purification (27)
Buffer Exchange (27)
Concentration (49)
Conjugation (1)
Desalting (27)
Diafiltration (42)
DNA Concentration (27)
mAB Production (3)
Microfiltration (145)
mRNA concentration (8)
Protein (23)
Protein Concentration (27)
Purification of mAbs, ADC, vaccines, viral vectors, and recombinant proteins (26)
Recombinant Protein Production (3)
Single Use Processing (24)
Ultrafiltration (803)
Vaccine (23)
Vaccine Production (3)
Viral Vector Vaccine (3)

Application Area

Buffer exchange (6)
Concentration (6)
Monoclonal antibody production (6)
Pilot (23)
Preclinical and clinical studies (23)
Process development (23)
Production (23)
Recombinant protein production (6)
Transferring (10)
Vaccines (6)

Bacterial Endotoxins

< 0.18 EU/mL as determined by the LAL test (164)
< 0.25 EU/mL as determined by the LAL test (8)

Bag Volume

1-20 L (20 L 3D mixing bag) (1)
1.5 - 3 L (SU) (1)
5, 10, 20 L (SU) (1)

Capsule/Cartridge Format

Bioproducer (129)
Discover (128)
Explorer (3)
Grand (20)
Grand XL (53)
Investigator (130)
mini Bioproducer (127)
Pioneer (42)
Researcher (129)
Researcher XL (126)

Cassette Capacity

Sartocon® Cassettes: ≤ 10 (13)
Sartocon® Cassettes: ≤ 20 (7)
Sartocon® Cassettes: ≤ 5 (1)
Sartocon® Slice 200 Cassettes: ≤ 2 (1)

Channels

4 (3)
8 (2)
12 (2)
16 (1)

Connections

DIN (5)
ISO (5)
JIS-G (6)
No (1)
TC (4)
Zoll (5)

Connector Inlet

0.5" AseptiQuik® G (5)
1" Tri-clamp (2)
1-1/2" Tri-clamp (3)

Connector Outlet

0.5" AseptiQuik® G (5)
1" Tri-clamp (2)
1-1/2" Tri-clamp (3)

Connector(s)

AseptiQuik® Connector (2)
AseptiQuik® G (1)
Feed/Retentate: 0.75" TC Permeate: 0.375" hose barb (252)
Feed/Retentate: 1.5" TC Permeate: 0.5" TC (126)
Feed/Retentate: 1.5" TC Permeate: 0.75" TC (126)
Feed/Retentate: 1.5" TC Permeate: 1" TC (126)
Feed/Retentate: 2.5" TC Permeate: 1" TC (71)
Feed/Retentate: Luer Lock Permeate: Luer lock (167)
Female Luer lock threads, 316L (1.4404/1.4435) (1)
Luer connectors (3)
Luer lock (1)
MPC (7)
MPC female 0.375" (1)
MPC female 0.5" (1)
Permeate: 0.25" AseptiQuik® G, MPC female 0.25" (1)
Retentate: 0.375" AseptiQuik® G, MPC female 0.375" (1)
Tri-clamp (7)
0.25" MPC male (1)
0.375" AseptiQuik® G (1)
0.5" AseptiQuik® G (6)
0.5" Tri-clamp (1)
0.75" Tri-clamp (4)
0.75" Tri-clamp sanitary flange (1)
1" Tri-clamp (2)
1"-1.5" Tri-clamp sanitary flange (DN25) (23)
1-1/2" Tri-clamp (3)

Delivery Condition

Gamma irradiated (13)
Non-Sterile (2)
Sterile (10)

Dimensions WxDxH

Base Unit: 1,430 x 755 x 1,755 mm (nominal) With 2nd bag holder: 1,875 x 755 x 1,755 mm (nominal) (1)
Basic Unit: 185x92x196 cm (1)
1,100 × 800 × 680 mm (1)
19.5X13X6.5 (3)
25,4X11X4,5 (1)
62 x 42 x 79,5 cm (1)
115,8 x 42 x 79,5 cm (1)
120 × 160 × 275 mm (1)
120 × 190 × 225 mm (1)
122.5 × 168.2 ×18.15 mm (single adapter )330.0 × 173.4 × 250.1 mm (stand with adapter) (1)
124 x 42 x 79,5 cm (1)
177,8 x 42 x 79,5 cm (1)
186 x 42 x 79,5 cm (1)
239,8 x 42 x 79,5 cm (1)
240 × 348 × 1230 mm (7)
240 × 348 × 459 mm (8)
240 × 348 × 695 mm (5)
301,8 x 42 x 79,5 cm (1)
602 × 440 × 610 mm (1)
620 × 600 × 540 mm (4 channel module) (1)

Display

Colored Touchscreen (1)
Yes (1)

Display Size

12" (800 x 600 pixel) (1)
22" (1)

Feed / Retentate

Volume: 3.3 L (1)
10 mm (1)
22.1 mm (3)
23 mm (4)
26 mm (3)
29.7 mm (3)
34.8 mm (2)
35.7 mm (2)
38 mm (1)
38.4 mm (2)

Fiber ID

0.5 mm (359)
1.0 mm (509)

Filter Class

Microfilter (12)
Ultrafilter (166)

Filter Configuration

Flush Cassette without Membrane (2)
Sartocon Cassette (13)
Sartocon® ECO (45)
Sartocube Cassette (10)
Slice 200 Cassette (18)
Slice 200 ECO Cassette (8)
Slice 50 Cassette (12)
Slice Cassette (17)
Slice Disposable Cassette (1)
Slice ECO Cassette (23)

Filter Diameter

0.33 cm (42)
0.95 cm (125)
2.00 cm (252)
3.30 cm (126)
7.00 cm (126)
9.00 cm (126)
15.28 cm (71)

Filter Format

Capsules (1)
Cassettes (189)
Dummy Cassettes (2)

Filter Holder Type

Capsules Holder (10)
Process Filter Holder (12)

Flow Channel Geometry

Microfilter Wide Spacer (12)
Protein conc. <20% /or viscosity max.3cp (70)
Protein conc. >20% /or viscosity above.3cp (93)
Screening Device (11)

Gamma Irradiation

Minimum dose of 25 kGy (10)
yes (4)

Hold-up Volume

< 20 mL (1)
~ 400 mL (1)
200 mL (1)

Including Control Station

No (3)
Yes (4)

Inner Diameter

1" (6)
1/2" (4)

Length

12" (273)
24" (310)
41" (251)
43" (34)
371 mm (4)

Materials of Construction

Stainless steel (1)
304 stainless steel (1)

Maximum Inlet Pressure

3 bar (31)
4 bar (155)

Maximum Operating Pressure

3 bar (43.5 psi) (9)
3 bar (44 psi) (1)
3.5 bar (43.5 psi) (1)
4 bar (1)
4 bar (58 psi) (13)
4 bar (60 psi) (1)
4 bar | 58 psi (1)

Membrane Area

Cassette: up to 14 m² (optional up to 21 m²) Hollow Fiber: up to 10 m² (12", 24", 41") (1)
0.1 - 0.5 m² (optionally 0.7 - 2.1 m²) (1)
0.14, 0.28, 0.42, 1.4 m² (1)
0.2 m² (1)
50 cm² - 0.14 m² (1)

Microfilter

0.1 µm Polyethersulfone Microfilter Membrane (4)
0.45 µm Hydrosart Microfilter Membrane (1)

Minimum Operating Volume

< 20 mL (1)
< 30 mL (1)
Concentration | diafiltration: about 15.9 L Final concentration: about 6.9 L (1)
~ 600 mL (1)
~200 mL (1)
5 mL (9)

Mirror Inverted

No (14)
Yes (8)

Operating Pressure

Max. 4 bar | 58 psi (10)
4 bar (4)

Pack Size

1 (130)
1-pack (868)
2 (4)
3 (1)
5 (5)

pH Stability

pH 1 - 14 (20)
pH 1 – 14 (65)
pH 2 - 14 (28)
pH 2 – 14 (72)

Pore Size

0.1 µm (4)
0.1µm (38)
0.2 µm (4)
0.2µm (39)
0.45 µm (4)
0.45µm (38)

Power Requirements

100 - 120 V, 50/60 Hz, 9A220 - 240 V, 50/60 Hz, 5A (1)
230 VAC | 50 Hz 2 Amp;120 VAC | 60 Hz 3 Amp (1)
230 VAC | 50 Hz 2.5 Amp;120 VAC | 60 Hz 4 Amp (1)
230 VAC | 50 Hz 3 Amp; 120 VAC | 60 Hz 4 Amp (1)
380-480V 50 | 60 Hz Option 1: Legrand L2220-P Plug 5-Wire 20A 277/480V Turnlok® Option 2: Mennekes 13522 CEE Plug Xtra S 16A 5p 6h 400V IP54 (1)

Process Step

Buffer Preparation (10)
Cell Harvest & Downstream Processing Intermediates (10)
Clinical Trial Manufacturing (15)
Commercial Manufacturing (7)
Drug Product Formulation (10)
Drug Substance Purification (10)
Media Preparation (10)
Pilot (9)
Process Development (11)

Quality Standards

Biological Reactivity Tests: Classified USP Class VI (passed USP <87> and USP <88> testing), Passed Cytotoxicity Test according to ISO 10993-5 FDA: All components conform to the requirements of the FDA Title 21, Chapter 177 TSE-BSE status: Conform to the European Guidance EMA/410/01 rev 03 and the European Pharmacopeia (EP) 5.2.8 (1)
Components are compliant with EMA410/01 Rev3 requirements with regards to TSE | BSE (10)
Feature components tested for biocompatibility and certified according to USP<88 (10)
Manufactured according to a validated assembly process (10)
Manufactured in a controlled environment (Class 7 in operation according to ISO 14644) (10)
Supplied double-bagged and irradiated with a minimum dose of 25 kGy (10)
The quality management system is ISO 9001 compliant (10)

Recommended Batch Volume

0.56-2.8 l (21)
0.98-5.6 l (21)
1-6 l (42)
1.4-11.2 l (42)
2-12 l (42)
3-25 l (42)
3-80 mL (21)
5-50 l (42)
10-100 l (42)
10-250 ml (42)
17-130 mL (21)
25-100 l (42)
25-250 l (42)
50-250 l (42)
50-400 ml (42)
80-850 ml (24)
80-850 mL (17)
100-500 l (53)
200 - 2000 L (1)
250-800 l (26)
400-1500 l (34)
400-2000 ml (45)
560-2800 ml (21)
700-4000 ml (39)
980-5600 ml (21)
1000-8000 ml (42)

Scale

Lab (175)
Pilot (379)
Process (333)

Sensors

Conductivity (2)
Flow (3)
No (4)
pH (2)
Pressure (3)
Temperature (2)
UV (1)
Yes (5)

Sterilization Method

Autoclavable & In-Line Steam Sterilizable (1)
Gamma irradiation (12)

Temperature Control

Refrigerated and heated (1)
Yes (1)

Total Weight

Basic Unit: 700 kg (1)
~ 120 kg (~265 lbs.) (1)
~ 35 kg (77 lbs.) (1)
4 kg (1)
54 kg (119 lbs.) (1)
450 kg (1)

Tube Length

1500 mm (3)
3000 mm (3)
5000 mm (4)

Tube Size (ID – OD)

Permeate: 1/4" - 7/16" and 1/4" - 1/2" (1)
Retentate: 3/8" - 5/8" and 1/4" - 7/16" (1)
¼” (6.4 mm) (2)
1" × 1-3/8" (25.4 mm × 34.9 mm) (3)
1/2" (1)
1/2" - 3/4" (1)
1/2" × 3/4" (12.7 mm × 19.1 mm) (5)
1/4" - 7/16" (2)
1/8" - 14" (1)
3/4" × 1-1/8" (19.1 mm × 28.6 mm) (2)
3/8" (1)
3/8" - 5/8" (1)
3/8” (9.6 mm) (2)

Tube Type

Extension line (7)
Reinforced line (3)

Tubing

Braided Silicone (Tuflux® SIL Braided) (3)
Platinum cured silicone, reinforced in high pressure sections (4)
Platinum-cured silicone, reinforced in high-pressure sections (6)
Silicone (5)
TPE (C-Flex®) (2)

Tubing Material

Platinum-Cured Silicone (6)
Platinum-Cured Silicone with PET reinforcement (9)
Silicone (1)
Synthetic Thermoplastic Elastomer (2)
TPE (1)

Type

Aseptiquik® (1)
Buffer & WFI (1)
Diafiltration (2)
E-Screen (High viscosity) (72)
ECO Screen (Low viscosity) (40)
Feed (4)
hydraulic (12)
manual (8)
Media Transfer (1)
Permeate (2)
Permeate & Retentate (1)
Permeate 1/2 (1)
Permeate 2/2 UV (1)
Prefiltration (1)
Pressure gauge (1)
Pump Head (1)
Q-Screen (Medium viscosity) (4)
Retentate (3)
Silicone gasket (1)
Stainless steel holder (1)
Stainless steel hose connector to 1-1 1/2" Tri Clamp flange (1)
Torque wrench (1)
Tri-Clamp (1)
10L bag (1)
20L Bag (1)

Ultrafilter

Albumin retentive Polyethersulfone Ultrafilter Membrane (3)
1 kD Polyethersulfone Ultrafilter Membrane (5)
5 kD Hydrosart® Ultrafilter (1)
5 kD Polyethersulfone Ultrafilter Membrane (6)
8 kD Polyethersulfone Ultrafilter Membrane (4)
10 kD Hydrosart® Ultrafilter (1)
10 kD Polyethersulfone Ultrafilter Membrane (7)
30 kD Hydrosart® Ultrafilter (1)
30 kD Polyethersulfone Ultrafilter Membrane (7)
50 kD Polyethersulfone Ultrafilter Membrane (5)
100 kD Hydrosart® Ultrafilter (1)
100 kD Polyethersulfone Ultrafilter Membrane (7)
300 kD Hydrosart® Ultrafilter (1)
300 kD Polyethersulfone Ultrafilter Membrane (6)

Usage

Reusable (413)
Single-use (455)

Volume

30 L to >2,000 L (13)
200 L to >2,500 L (7)
200 mL to 100 L (1)

Tangential Flow Filtration (TFF) (1173)

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