LipidBrick®

LipidBrick^® is a unique library composed of innovative proprietary imidazolium-based cationic lipids dedicated to the formulation of lipid nanoparticles (LNPs). These active lipids safeguard mRNA molecules and enhance the transfection ability of LNPs. Each LipidBrick^® lipid is permanently charged; therefore, unlike ionizable lipids, it confers an overall positive charge to LNPs, which induces extra-hepatic tropism. In addition, delivery efficacy and biodistribution can be fine-tuned by screening the LipidBrick^® library to select the most suitable LipidBrick^® lipid for each specific application therapeutic need.

Key Benefits:

• Efficient: Modulate LNP properties to adapt biodistribution to therapeutic goals.

• Secure: Unique structure protected by an independent patent held by Polyplus (now part of Sartorius).

• Time-Saving: In vitro and in vivo proof of concept studies have been successfully performed.

• Flexible: Versatile library for selecting the best LipidBrick^® for each application.