CIMmultus® Swiper 40 mL cGMP Monolithic Column (2μm)

CIMmultus^® is a unique and industry-proven line of pre-packed chromatographic monolithic columns featuring large flow-through channels, designed for working with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), virus-like particles and exosomes. CIMmultus^® columns can be used as single-use disposable or multi-use columns. They are available in a variety of volume ranges – from 1 mL for screening and method development purposes to 8000 mL for industrial manufacturing.

CIMmultus® Swiper is a multimodal chromatography suitable for capturing various RNA molecules, including mRNA, saRNA, circular, and non-coding RNA, with or without the presence of a poly-A tail. CIMmultus swiper columns are reusable and available ready-to-use for process development to commercial manufacturing scale.

Swiper features and benefits:

• Multimodal chromatography ligand that combines elements of hydrogen bonding with anion exchange chromatography
• Presents a valuable tool for various nucleic acids
• Suitable for the purification of non-polyadenylated RNA
• Tailored for sensitive and large RNA constructs, ensuring optimal performance and integrity
• Purification conducted under mild loading conditions and neutral pH elution presents a tailored purification process to meet specific research needs
• Elution by increasing pH at low conductivities facilitates the desalting of nucleic acids, ensuring enhanced purity