BioPAT® ViaMass Connect Hub (4-way)

One of the most requested parameters in industrial cell cultivation is the monitoring of biomass. The knowledge of the biomass progress during a fermentation process gives deeper process knowledge and understanding. Therefor it enables the control of the biomass and helps to define feeding, harvest or infection points. Offline methods like visual cell counting or semi-automated systems still dominated the biomass measurement in industrial cell cultivation. But these offline methods based on taking a representative sample can not monitor the process continously. The BioPAT^®Viamass biomass measurement system enables the field-proven sensor technology used for decades in stainless steel fermenters to be utilized in single-use bioreactors. Based on impedance spectroscopy, this sensor technology measures the specific capacitance of the culture medium and the cells, providing an excellent correlation to viable biomass. Integrated into the bioreactor’s DCU and Biobrain^® control system, BioPAT^® Viamass permits automatic monitoring and control of viable biomass.

• Reduces the need for manual sampling, lower risk of contamination due to lower sampling needs
• Easy to use plug and play operation for rapid cell expansion
• Real-time measurement of and feedback on viable biomass
• Decreased labor and laboratory costs for offline analysis
• Ensures batch-to-batch consistency
• Improved data gathering
• Eliminates operator influence that occurs in manual biomass measurements