Biomass is one of the most important parameters in commercial-scale cell cultivation. The more details you know about a fermentation process in progress, the better you can determine the optimal feed and harvest times as well as infection points.
So far, offline methods, such as visual cell counting or semi-automatic systems, have dominated biomass measurements. However, these require representative sampling, which prevents continuous biomass measurement during a batch in progress.
Moreover, offline methods do not allow real-time monitoring and control as analysis takes a long time. The BioPAT® Viamass biomass measurement system enables the field-proven sensor technology used for decades in stainless steel fermenters to be utilized in single-use bioreactors. Based on impedance spectroscopy, this sensor technology measures the specific capacitance of the culture medium and the cells, providing an excellent correlation to viable biomass.
Combined with a sophisticated automation platform, BioPAT® Viamass along with the versatile Biobrain® Suprvise software suite ensures 100% traceable documentation of a process run. Using BioPAT® Viamass together with the Biobrain® Supervise family delivers decisive advantages, particularly for developing control strategies.
