Celsius® S3 Benchtop System

The Celsius® S3 Benchtop System is a laboratory instrument made to evaluate freeze & thaw processes of new drug candidates in single-use bags with full scalability to production-scale Celsius® platforms (FFT, FFTp and CFT).

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The Celsius® S3 Benchtop System is the only lab-scale freeze & thaw system for single-use bags that is scalable to our production-scale Celsius® platforms (FFT, FFTp and CFT). This system is a tool to execute freeze & thaw process development and stability studies using a minimal amount of product.

Scalability

Using the same freeze & thaw critical process parameters and materials of construction as seen in all Celsius® Paks, the Celsius® S3 Benchtop System ensures unmatched scalability across systems of all scales.

Ease of Use

The CryoPilot Control Unit provides automated operation and data collection. The Celsius® S3 Benchtop System freezes and thaws 1 to 10 product samples per run. Lab-scale Celsius® Pak PDS are available in 30mL and 100mL nominal fill volumes with various filling port and thermowell configurations.

Improved Process Validation

The Celsius® S3 Benchtop System offers excellent batch-to-batch reproducibility as well as consistent product stability after freezing, thawing, and storing. The Celsius® S3 Benchtop System allows for documented and reproducible freeze & thaw processes, thus facilitating validation of your freeze & thaw operations.

Celsius® S3 Benchtop System Applications:

  • Process development studies to understand decoupling (hold) steps during downstream processing, e.g., frozen storage of process intermediates or drug substances. Explore the Celsius® technology for future scale-up. (FFT, FFTp and CFT)
  • Scale-down storage and transportation studies (using minimal volumes as low as 20mL) for understanding extended drug substance storage and shipping in terms of time and temperature
  • Formulation development of freeze & thaw compatible formulations for drug substances
  • Stability Studies in accordance with industry guidelines, conducted in freezing and thawing conditions as well as in a container closure system that is the same as or simulates the packaging proposed for freezing, storage, shipping, and thawing at production-scale

Accessories Information

  • Software
    Cryopilot® 5  

Applications

  • Application Area
    Frozen storage & shipping  
  • Process Step
    • Cell Harvest & Downstream Processing Intermediates  
    • Drug Substance Purification  
    • Drug Product Formulation  
    • Lab-scale Freeze & Thaw  

Dimensions

  • Dimensions WxDxH
    1880 x 760 x 710 mm  

Features

  • Languages
    English  
  • Load Capacity
    10 × Lab-scale Celsius® Pak  

General Specifications

  • Additional Product Specifications
    Control unit: Laptop computer  
  • Temperature Range
    -60 °C - + 40 °C  

Materials of Construction

  • Materials of Construction
    • 302/304 Stainless Steel  
    • 6061-T6 aluminum  
    • 5052 aluminum  
    • transparent PVC cover  

Product Information

  • Brand
    Celsius® S³  
  • Freezer Technology
    Lab-scale freezing  

Volume

  • Working Volume
    20 mL – 1 L  
  • Lab-scale Celsius® Pak - Luer - EVA + TPE
    Item no.
    Lab-scale-Celsius-Pak-Luer-EVA-TPE

    Lab-scale Celsius® Paks, when combined with the Celsius® S3 Benchtop System, allow users to optimize their freeze & thaw processes in the lab before scaling-up to the production system.

    These small-scale, single-use solutions simplify scalability when transitioning from lab work to production.

    Web prices – only available through online purchase

  • Lab-scale Celsius® Pak - Luer - EVA + Silicone
    Item no.
    Lab-scale-Celsius-Pak-Luer-EVA-Silicone

    Lab-scale Celsius® Paks, when combined with the Celsius® S3 Benchtop System, allow users to optimize their freeze & thaw processes in the lab before scaling-up to the production system.

    These small-scale, single-use solutions simplify scalability when transitioning from lab work to production.

    Web prices – only available through online purchase

  • Lab-scale Celsius® Pak - MPC - EVA + Silicone
    Item no.
    Lab-scale-Celsius-Pak-MPC-EVA-Silicone

    Lab-scale Celsius® Paks, when combined with the Celsius® S3 Benchtop System, allow users to optimize their freeze & thaw processes in the lab before scaling-up to the production system.

    These small-scale, single-use solutions simplify scalability when transitioning from lab work to production.

    Web prices – only available through online purchase

  • Lab-scale Celsius® Pak - MPC - EVA + TPE
    Item no.
    Lab-scale-Celsius-Pak-MPC-EVA-TPE

    Lab-scale Celsius® Paks, when combined with the Celsius® S3 Benchtop System, allow users to optimize their freeze & thaw processes in the lab before scaling-up to the production system.

    These small-scale, single-use solutions simplify scalability when transitioning from lab work to production.

    Web prices – only available through online purchase

  • Lab-scale Celsius® Pak - Luer - EVA
    Item no.
    Lab-scale-Celsius-Pak-Luer-EVA

    Lab-scale Celsius® Paks, when combined with the Celsius® S3 Benchtop System, allow users to optimize their freeze & thaw processes in the lab before scaling-up to the production system.

    These small-scale, single-use solutions simplify scalability when transitioning from lab work to production.

    Web prices – only available through online purchase