CIMmultus® C4 HLD 4000 mL cGMP (2 μm)
CIMmultus® is a unique and industry-proven line of pre-packed chromatographic monolithic columns featuring large flow-through channels, designed for working with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), virus-like particles and exosomes. CIMmultus® columns can be used as single-use disposable or multi-use columns.
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*Custom/bulk order quotes are provided within 72 hours of request.
CIMmultus® Monoliths are reusable chromatography devices for scalable high-resolution purification of complex biological samples. Inside the custom designed housing is a single piece stationary phase with homogeneous channel size and surface chemistry. This stationary phase is designed to simplify method transfer from development into production.
Without the need for column packing, CIMmultus® Monoliths are ready for use out of the box.
This high-performance ion exchange column is primarily intended for fast and efficient purification of biomolecules such as large proteins, viruses and virus like particles through their ionic interaction with the monolith. The following information is being provided to ensure proper product care and optimal product performance.
C4 (butyl) high ligand density (HLD) features:
- Strong cation exchanger
- Working range, pH 2–13
- Binds molecules with predominantly positive charge, repels molecules a predominantly negative charge
- Use for capture, intermediate, or polishing steps in either bind-elute or flow-through mode
- High capacity for purification of virus and VLP particles, large proteins
- Sanitizable with 1 M NaOH
ConnectorsTC 1 in. (25 mm), 8 mm ID bore
Channel Size2 µm
Column Tube Length205 mm
Inner Diameter255 mm
Outer Diameter300 mm
Flow Rate500–4000 mL/min | 15–135 cm/h | 0.15–1 CV/min
Materials of Construction
Materials of ConstructionPoly(butyl methacrylate -co- ethylene dimethacrylate)
Maximum Operating Pressure0.7 MPa | 7 bar | 100 psi
Recommended Operating Temperature4 °C (39 °F) to 40 °C (104 °F)
pH StabilityWorking range 3–13, cleaning in place 1–14
Bed Volume4000 mL
LigandC4 HLD (hydrophobic, butyl – high ligand density)
Package TypeIndividually Packed