CM Ceramic HyperD® F PRC Column - 1 mL

CM Ceramic HyperD® is a weak cation exchanger for biomolecule purification. Changes in conductivity and pH can optimize purification steps by utilizing the charge change on protein and ligand. Pre-packed columns simplify resin screening and selection, and are ideal for process step optimization. The RoboColumn format is especially suited to high throughput process development (HTPD).

Item No.: 

*Custom/bulk order quotes are provided within 72 hours of request.

CM Ceramic HyperD® F ion exchange chromatography resin is designed using proprietary 'gel-in-a-shell' design that provides rapid mass transfer and effective binding. It relies on a high capacity hydrogel, polymerized within the gigapores of a rigid ceramic bead.

Features and Benefits

- High dynamic binding capacity at high flow rates
- Truly rigid, non-compressible resin
- Salt tolerant CM Ceramic HyperD™ F resin reduces Ultrafiltration/Diafiltration (UF/DF) requirements


- Recombinant proteins
- Purification of enzymes, plasma proteins
- Vaccines
- Direct capture of monoclonal antibodies
- IgM


  • Application
    Resin screening and process optimization  

Compliance Information

  • Quality Standards
    • CoA  
    • RSF  


  • Bead Size
    50 µm  
  • Bed Height
    50 mm  
  • Dimensions
    5 x 50 mm  

General Specifications

  • Flow Rate
    typically 300 to 600 cm/h (1 to 2 mL/min) with < 1.5 bar (22psi)  
  • Resin Format
    Pre-packed column  

Materials of Construction

  • Base Matrix
    Ceramic Beads  
  • Materials of Construction

Operating Conditions

  • Operating Pressure
    < 3 barg (44psi)  
  • pH Stability
    1 to 14 (short term), 2 to 12 (long term)  

Physicochemical Information

  • Bed Volume
    1 mL  
  • Ligand
  • Ligand Density
    250-400 µeq/mL  
  • Reference Protein
    Human polyclonal IgG  
  • Typical Dynamic Binding Capacity 10% per mL
    > 60 mg/mL hIgG  

Product Information

  • Brand
    CM Ceramic HyperD®  
  • Pack Size
    1 column per pack  
  • Pack Volume
    1 mL  
  • Resin Delivery Condition
    20% EtOH/150 mM NaCl  
  • Resin Type
    Weak cation exchanger  
  • What you receive
    1 column, instructions  

Storage Conditions

  • Storage Conditions
    20% EtOH/1 M NaCl