MVDA Spectro SIMCA® 17 - Onsite course

Course Objective

The objective of this course is to guide the attendees through their journey from importing the spectroscopy dataset to a multivariate monitoring model based on their spectroscopy data. Spectra tables are translated into interpretable charts and plots which simplifies the understanding as well as analysis of deviations in spectra or predictions. Multivariate technology is the science of separating the signal from the noise in data with many variables and presenting the results in a simple graphical format. Quickly go from a complicated table of numbers to a simple plot of the essentials. The key to unlocking the information in your data lies in the correlations among the variables, not in the variables themselves.

Who Should Participate?

In addition to Ambr^® and STR^® users with BioPAT^® Spectro, this course is for researchers, scientists and engineers from all sectors of biopharma with a lot of process understanding but with no or limited statistical background. Typical applications include product development, process improvement/optimization and investigations of deviation.

Selected Course Content

• Organization, visualization and treatment of different types of data
• Multivariate data modelling and diagnostics
• Understanding PCA, PLS and OPLS
• Model interpretation
• Possibilities for real time process monitoring

Language Information

Seminars are given in the language stated. In-depth discussion, course material and printed material are in English hence knowledge of English is required.

Schedule

Session 1 & 2: Introduction to MVDA, PCA Applications

• Introduction to the Basics of Spectroscopy.

• Introduction to PCA for overview of data tables.

• Variable scaling and centering.

• Spectral Pre-processing.

• Model evaluation.

• IPCA applications – how does PCA bring value?.

• Software click-along exercise.

Session 3&4: Data Preprocessing, OPLS Applications, Advanced Topics

• Introduction to Multivariate Calibration.

• Using SIMCA®’s Calibration Wizard.

• Introduction to PLS and OPLS

• Considerations for Calibration and Validation data sets

• Developing a Reliable Training Set.

• Interpretation of Loadings

• Model Robustness

• Software click-along exercise

• Course debriefing and final Q&A

Course Material and Software

The electronic course material (course slides and exercises) and the SIMCA course license will be sent out by email two weeks before the course starts. SIMCA needs admin rights to be installed so please contact IT soonest. Sartorius cannot help you to install SIMCA. We recommend you have two screens or one projector and one PC in order to follow the course and demos easily. However this is not required.

Cost and Conditions

The course fee is 1630€ per person.

Cancellations received later than two weeks before the course starts will not be refunded. For courses cancelled more than two weeks before the course starts, Sartorius Stedim Data Analytics AB will retain 10% of the course fee to cover administrative costs and the rest of the amount will be refunded.

Course participant(s) can be substituted by the registering company as long as Sartorius Stedim Data Analytics AB is notified.

Sartorius Stedim Data Analytics AB are providing courses based on a sufficient number of registrants. Therefore, Sartorius Stedim Data Analytics AB reserves the right to cancel the course 14 days prior to the course start date, if the number of registrants is too low. Full refund will be made to these registrants. A 10% discount will be made to any registrant(s) enrolling in the next available course.