Sartobind® S membrane adsorber units combine the advantages of convective media and ion exchange chromatography for rapid and easy contaminant removal or capture of virus and virus like particles.

Item No.: 
96IEXS42E4J11--A

*Custom/bulk order quotes are provided within 72 hours of request.

Sartobind® S membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Sulfonic acid ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.

Applications:

The S membrane adsorber is successfully used in FDA-approved drug manufacture to remove host cell proteins at high flow rates. As a cation exchanger it displays not only aggregate removal capabilities but typically at least ten-fold higher binding capacity for viruses and virus-like-particles (VLP).

Benefits:

The Sartobind S adsorber speeds up the production process by high flow rate and opens new opportunities for the purification of therapeutic proteins and vaccines.

  • High speed host cell protein removal up to 30 bed volumes/ min
  • Aggregate removal

Easy to use:

  • Plug and play devices from 0.08 ml to 5 l
  • Can be used like a filter
  • Flow rate up to 30 bed volumes/min
  • Disposable or re-usable

Applications

  • Application
    • Capture  
    • Polishing  

Compliance Information

  • Biological Reactivity
    All materials of this filter element meet the requirements of the current USP Biological Reactivity tests <88> for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).  

Connections (Physical)

  • Connectors
    Luer female  

Dimensions

  • Bed Height
    8 mm  
  • Dimensions WxDxH
    70 x 54.5 cm  
  • Membrane Area
    728 cm²  

Features

  • Reusable
    Yes  

Materials of Construction

  • Housing Material
    Polypropylene (PP)  
  • Materials of Construction
    Polypropylene; Polyester  
  • Membrane Material
    Stabilized reinforced cellulose  

Operating Conditions

  • Maximum Operating Pressure
    0.4 MPa  
  • Maximum Venting Pressure
    0.5 bar, 0.05 MPa, 7 psi  
  • Recommended Flow Rate
    100 mL/min  
  • pH Stability
    pH 3 – 14 (short term)  

Physicochemical Information

  • Bed Volume
    20 mL  
  • Chemical Compatibility
    Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents  
  • Ligand
    Sulfonic acid  
  • Ligand Density
    2 – 5 µeq/cm²  
  • Pore Size
    3 – 5 µm  
  • Reference Protein
    Lysozyme  
  • Thermal Stability
    Sartobind® capsules with ion exchange membranes can be autoclaved at 121 °C for 30 min. We recommend one autoclaving cycle only.  
  • Typical Dynamic Binding Capacity 10% per unit
    0.5 g  
  • Void Volume
    32 mL  

Product Information

  • Brand
    Sartobind® S  
  • Membrane Adsorber Format
    Capsules  
  • Membrane Type
    Strong cation exchanger  
  • Pack Size
    4  
  • Type
    Membrane adsorber  
  • What you receive
    • 4 capsules  
    • 8 adapters Luer male to UNF 10-32 female  
    • 1 operating instruction  
    • 1 certificate