Sartobind STIC® PA Nano 1 mL with 4 mm bed height

Sartobind STIC® PA (primary amine) anion exchange membrane overcomes reduced binding capacity for host cell protein removal and can be used in high-salt conditions.

Item No.: 

*Custom/bulk order quotes are provided within 72 hours of request.

Sartobind STIC® PA removes contaminants at high salt. Salt-tolerant interaction chromatography (STIC) with PA ligand is based on anion-exchange chromatography (AEX) principles. AEX is the established method for removing process-derived contaminants such as host-cell proteins (HCP), DNA, endotoxins, and adventitious and endogenous viruses. It is performed during the downstream processing of monoclonal antibodies (mAbs) in flow-through mode. The process is driven by throughput and not by mass, and thus membrane chromatography (MC) is advantageous over columns for contaminant removal, as membranes run up to two orders of magnitude higher flow rates. Membranes are easy to operate and can be disposed of after one use, just like filters, to save on validation cost.


Current mAb downstream processes consist of at least one initial capture and one AEX chromatography step. The limitation of AEX steps is often that the Q chemistry requires low-salt conditions. In processes with cation exchange (CEX) as the second chromatography step, the CEX pool needs to be diluted to conductivities of 4-7 mS/cm to reestablish binding conditions for the following AEX step. The Sartobind STIC PA membrane is composed of cross-linked, regenerated macro-porous cellulose. The primary amine ligand is attached to the matrix at approximately six-fold higher ligand density than that of Q membrane. Both the free amine and the high ligand density were crucial for developing its high salt tolerance.


The Sartobind STIC® adsorber speeds up the production process by high flow rate and opens new opportunities for the purification of therapeutic proteins and vaccines.

  • No dilution of CEX pools necessary
  • Host cell proteins up to 10kg/l (product load/liter membrane)
  • Viruses >4 log
  • DNA at up to 1.5 M NaCl
  • Endotoxins >4 log

Easy to use:

  • Plug and play devices from 0.08 ml to 1.6 L
  • Can be used like a filter
  • Flow rate up to 30 bed volumes/min
  • Disposable after one use


  • Application

Compliance Information

  • Biological Reactivity
    All materials of this filter element meet the requirements of the current USP Biological Reactivity tests <88> for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).  

Connections (Physical)

  • Connectors
    Female Luer lock  


  • Bed Height
    4 mm  
  • Dimensions
    37 x 31 mm  
  • Membrane Area
    36.4 cm²  


  • Reusable

Materials of Construction

  • Housing Material
    Polypropylene (PP)  
  • Materials of Construction
    Polypropylene, polyester  
  • Membrane Material
    Stabilized reinforced cellulose  

Operating Conditions

  • Maximum Operating Pressure
    0.4 MPa  
  • Maximum Venting Pressure
    0.5 bar, 0.05 MPa, 7 psi  
  • Recommended Flow Rate
    20 mL/min  
  • pH Stability
    pH 2 – 14 (short term)  

Physicochemical Information

  • Bed Volume
    1 mL  
  • Chemical Compatibility
    Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents  
  • Ligand
    Primary amine (PA)  
  • Ligand Density
    18 – 22 µeq/cm²  
  • Pore Size
    3 – 5 µm  
  • Reference Protein
    Bovine serum albumin (BSA)  
  • Thermal Stability
    Sartobind capsules with ion exchange membranes can be autoclaved at 121 °C for 30 min. We recommend one autoclaving cycle only.  
  • Typical Dynamic Binding Capacity 10% per unit
    50 mg  
  • Void Volume
    3.5 mL  

Product Information

  • Brand
    Sartobind® STIC PA  
  • Membrane Adsorber Format
  • Membrane Type
    Salt tolerant interaction membrane (anion exchanger)  
  • Pack Size
  • Type
    Membrane adsorber  
  • What you receive
    • 4 capsules  
    • 2 adapters Luer male to UNF 10-32 female  
    • 1 operating instruction  
    • 1 certificate  
  • Sartobind® Adapter UNF 10-32 female to Luer male

    Adapter UNF 10-32 female to Luer male for Sartobind®Material: natural PEEK