Sartobind® Q

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Sartobind® Q Sartobind® Q Sartobind® Q
 

Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.

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Sartobind® Q membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Quaternary ammonium ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.

Applications virus and VLP capture:

As size exclusion effects are negligible, they are suited for purification of viruses and display one order of magnitude higher dynamic binding capacity compared to resin. Viruses such as adeno- or lentiviruses are captured at high flow rates. The material allows also >100 cycles of re-use without loss of binding capacity.

Benefits capture:

  • High speed purification at 5 - 30 bed volumes per minute
  • No size exclusion effects for large proteins an viruses / VLPs
  • >10fold higher binding capacities compared to conventional resins

Applications flow-through polishing:

Sartobind Q is the perfect tool for the flow-through polishing of valuable proteins such as monoclonal antibodies. The bed volumes can be kept sufficiently small during the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins from such pharmaceutical proteins.

Benefits flow-through polishing:

  • Virus clearance > 6 log
  • DNA below detection limit
  • Host cell protein removal > 99 %
  • Endotoxin removal > 5 log
  • Save 80 % of column costs

Easy to use:

  • Plug and play devices from 0.08 mL to 5 L
  • Can be used like a filter
  • Flow rate up to 30 bed volumes/min
  • Re-usable or disposable

Application Notes

Sartobind® Lab Membrane Adsorbers Provide Constant Binding Capacities for More Than 100 Cycles
en 737.3 kB
High Throughput Screening Using Membrane Chromatography
en 791.7 kB
Host Cell Protein Removal - A Comparison Between Sartobind STIC® PA and Sartobind® Q
en 282.0 kB
Optimizing Adenovirus Purification Processes - Using Sartobind® Q and STIC PA Anion Exchange Membranes
en 659.3 kB
Endotoxin Removal - Ion Exchange Chromatography With Sartobind® Membrane Adsorbers
en 359.9 kB
Sartobind® Membrane Adsorbers for Capture and Polishing
en 1.1 MB
Virus Purification and Removal - Ion Exchange Chromatography with Sartobind® Membrane Adsorbers
en 522.2 kB
Scale up with Sartobind® Q pico — Miniaturized scaleable format for process developers
en 670.2 kB
DNA Removal Using Sartobind® Q in mAb Purification - Ion Exchange Chromatography With Sartobind® Membrane Adsorbers
en 399.4 kB
DNA Binding On Sartobind STIC® PA Compared to Sartobind® Q - Salt Tolerant Membrane Chromatography
en 599.0 kB

Datasheet

Sartobind® 96-Well Plates - High Throughput Screening With IEX and HIC Membrane Chromatography
en 376.4 kB
Sartobind® pico 0.08 mL — Membrane chromatography tool for process development
en 730.2 kB
Sartobind® Q and S, 4 and 8 mm Bed Height - Process-Scale Strong Ion Exchange Membrane Adsorbers
en 1.3 MB

Flyer

Sartobind® Selection Guide
en 827.1 kB

User Manual

Instructions for Use - Sartobind® 96-well plates — IEX (Q, S, STIC PA) and HIC (Phenyl) in 8-strips — For High Throughput Screening Based on Macroporous Membranes, 0.8 mm Bed Height
en 356.6 kB
Sartobind® pico 0.08 mL - Sartobind Q, S, STIC PA and Phenyl membrane adsorbers
en 905.4 kB

Product Information

  • Brand
    Sartobind® Q