Sartocube® Cassette | Hydrosart® | 100kDa | 3m² | 1pc.

Sartocon Hydrosart® cassettes are characterized by ultra-low protein adsorption, easy cleaning, higher yields, and long product life. Even with repeated use, Hydrosart® ultrafiltration membrane maintains it’s performance without fouling or loss of retention.

Sartocon® cassettes are self-sealing, feature low extractables and the enlarged feed and retentate ports lower system pressure drops.

Sartocon® cassettes are ideally combined with Sartorius Sartocon holders and systems.

Applications

Typical 100 kDa TFF Applications are Ultrafiltration and Diafiltration of

• Non-enveloped Viruses such as AVV and LV
• Virus like particles
• pDNA and mRNA
• Blood and Plasma
• Protein solutions
• Polysaccharide solutions
• Large mAb constructs
• Removal of Contaminants

Hydrosart® Membrane:

Hydrosart® high performance membrane is a stabilized cellulose-based membrane that has been optimized for biopharmaceutical process applications. Hydrosart® is stable across a broad pH range, is extremely hydrophilic, making it non-protein binding, and virtually non-fouling. Membrane depyrogenation can be accomplished by using NaOH even at elevated temperatures. These features make Hydrosart® an ideal membrane for biological applications.

Flow Channel Geometry

The Sartocon® family is available in two flow channel geometry versions. E-Screen filters are dominantly used for protein concentrations up to above 20% as well as viscosity conditions greater than 3 cp. ECO-Screen devices mainly used for water based protein solutions of below 20% protein concentration as well as lower than 3 cp viscosity allow economical optimized filtration runs.

Available Sizes and Cut-Offs

Sartorius Sartocon® and Sartocube® TFF cassettes are available for pilot- and production scale, and in Sartocon® Slice as well as Sartocon® Slice 200 format for reduced volume handling.

Cut-Offs:

E-screen: 2 | 5 | 10 | 30 | 100 | 300 kDa

ECO screen: 10 | 30 | 100 | 300 kDa

Regulatory Compliance

All product contact materials have passed the current USP Biological Test and Cytotoxicity Test. All materials are BSE and TSE free. The filtrate meets or exceeds the currently valid USP and EP for sterile Water for Injection, with respect to extractable substances, oxidizable substances and Bacteria Endotoxins.