Sartocon® Cassette | PES | 300kDa | 0.7m² | ECO

Sartocon® Polyethersulfone TFF cassettes are well established in the biotechnological and pharmaceutical industry. The PES membrane is a stable polymer that features a broad pH and temperature range. Membrane regeneration, storage and depyrogenation can be accomplished by using NaOH even at elevated temperatures.

Sartocon® cassettes are self-sealing, feature low extractables and the enlarged feed and retentate ports lower system pressure drops.

Sartocon® cassettes are ideally combined with Sartorius Sartocon holders and systems.

Applications

Typical 300 kDa TFF Applications are Ultrafiltration and Diafiltration of

• Large Viruses such as MVA for Smallpox and Monkeypox vaccine
• Virus like particles
• pDNA and mRNA
• Blood and Plasma
• Protein solutions
• Polysaccharide solutions
• Large mAb constructs
• Removal of Contaminants

Polyethersulfone Membrane

Polyethersulfone (PES) membrane is an established membrane polymer that is well suited to any biopharmaceutical process applications. PES membrane is a stable polymer that can operate in a broad pH and temperature range and withstand aggressive cleaning cycles.

Flow Channel Geometry

The Sartocon® family is available in two flow channel geometry versions. E-Screen filters are dominantly used for protein concentrations up to above 20% as well as viscosity conditions greater than 3 cp. ECO-Screen devices mainly used for water based protein solutions of below 20% protein concentration as well as lower than 3 cp viscosity allow economical optimized filtration runs.

Available Sizes and Cut-Offs

Sartorius Sartocon® and Sartocube® TFF cassettes are available for pilot- and production scale, and in Sartocon® Slice as well as Sartocon® Slice 200 format for reduced volume handling.

Cut-Offs:

E-screen: 1 | 5 | 8 | 10 | Albumin | 30 | 50 | 100 | 300 kDa

ECO screen: 10 | 30 | 100 | 300 kDa

Regulatory Compliance

All product contact materials have passed the current USP Biological Test and Cytotoxicity Test. All materials are BSE and TSE free. The filtrate meets or exceeds the currently valid USP and EP for sterile Water for Injection, with respect to extractable substances, oxidizable substances and Bacteria Endotoxins.