in vivo-jetRNA®+ is a lipid-based transfection reagent composed of preformed liposomes specifically developed for in vivo mRNA delivery. This reagent can be used to target unique or multiple organs, by using local or systemic injection routes, in various animal models (mice, rat, etc.). mRNA delivery using in vivo-jetRNA®+ is user-friendly, with a simple 2-step protocol and can be used for vaccination purposes, oncology studies, genome editing (e.g., CRISPR/Cas9 technology) or protein replacement. It is also a reliable and convenient positive control for the development of Lipid nanoparticles (LNPs).

Amount of Reagent
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in vivo-jetRNA®+ is a non-viral delivery solution composed of pre-formed lipid-based nanoparticles. It has been specifically developed for in vivo mRNA delivery. Its high delivery efficiency combined with its safety make in vivo-jetRNA®+ an innovative alternative to lipid nanoparticles (LNPs), with the added advantage of being user-friendly with a two-step protocol.

in vivo-jetRNA®+ can be used to deliver mRNA, self-amplifying RNA (saRNA), and guide RNA (gRNA) via systemic or local administration routes in various animal models, making it an ideal tool for scientists developing vaccines, protein replacement therapies, oncology treatment, or working on genome editing. It has also proven highly effective for ex vivo applications, such as the generation of mRNA CAR-T cells.

Key Benefits:

  • Efficient: 100% mRNA encapsulation leading to delivery results comparable to LNPs.
  • Time-Saving: Ready-to-use reagent that does not require formulation equipment.
  • Stable: Liposome transfection efficiency and size are stable over time.
  • Safe: Keep animals and organs healthy and do not trigger pro-inflammatory response.


  • Application
    in vivo and ex vivo delivery of mRNA/saRNA

Biological Information

  • Biodistribution & Injection routes
    Universal biodistribution: Any organ or tissue (depending on the injection route)
  • Molecule delivered
    mRNA, saRNA
  • Number of injections in mice
    1 mL is sufficient to perform 50 intravenous injections or 100 intramuscular injections in mice
  • Volume of mRNA Buffer
    60 mL

Compliance Information

  • Product Documentation
    • Protocol 
    • Certificate of Analysis 
    • Master Safety Data Sheet

General Specifications

  • Amount of Reagent
    in vivo-jetRNA®+ 1mL
  • Reagents and Kits Type
    in vivo-jetRNA®+

Product Information

  • Provided With
    mRNA buffer

Storage Conditions

  • Storage Conditions
    5 °C ± 3 °C