CMM HyperCel

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CMM HyperCel CMM HyperCel CMM HyperCel
 

CMM HyperCel is a hydrophobic cation exchanger designed for the capture of antibodies, antibody fragments, and recombinant proteins. It allows the separation of proteins with similar pIs and hydrophobicity by modulation of pH and conductivity.

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CMM HyperCel
CMM HyperCel

CMM HyperCel is a hydrophobic cation exchanger designed for the capture of antibodies, antibody fragments, and recombinant proteins. It allows the separation of proteins with similar pIs and hydrophobicity by modulation of pH and conductivity.

Item No.:
M_CMM_HyperCel

Overview

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CMM HyperCel resin is composed of a rigid cellulose matrix that has flow properties compatible with the needs of manufacturing scale protein production.

The proprietary ligand, containing both a primary amine and a carboxyl group, confers cation exchange and hydrophobicity properties to the chromatography resin. The flexibility of the ligand enables the separation of proteins with a large variety of isoelectric points and hydrophobicity levels, and multiple conditions can be employed to separate targeted molecules from contaminants.

Features and Benefits

  • Unique selectivity
  • High capacity mixed mode chromatography resin
  • High recovery, low elution volume
  • Easy CIP, NaOH stable

Applications

  • Capture of mAbs, Fab fragments and recombinant proteins from challenging feedstocks
  • Separation of proteins with similar isoelectric point and | or hydrophobicity at low or high conductivity

Compliance Information

  • Quality Standards
    • CoA
    • RSF (upon request)

Dimensions

  • Bead Size
    50 - 80 µm

Materials of Construction

  • Base Matrix
    Rigid cellulose beads

Operating Conditions

  • Operating Pressure
    < 3 barg (44psi)
  • pH Stability
    1 to 14 (short term), 2 to 13 (long term)

Physicochemical Information

  • Ligand
    Aminobenzoic acid
  • Ligand Density
    Av. 70 µeq/mL
  • Reference Protein
    • Bovine serum albumin (BSA)
    • Human polyclonal IgG
  • Typical Dynamic Binding Capacity 10% per mL
    > 50 mg/mL BSA at pH 4.5, 15 mS/cm; 60-100 mg/mL IgG at pH 4 to 5, 4-12 mS/cm

Product Information

  • Brand
    CMM HyperCel
  • Resin Type
    Mixed Mode cation exchanger

Storage Conditions

  • Storage Conditions
    20% EtOH/1M NaCl