Sartopore® 2 XLM | Cartridge | 0.1µm | 5"

Sartopore^® 2 XLM is specifically designed for sterile filtration and safe mycoplasma retention in cell culture media. A long filter life is guaranteed by the extremely asymmetrical and heterogeneous PES Membrane and allows a >50% better performance compared to existing 0.1 μm filter cartridges.

• Lowest filter consumption by high filtration capacity
• Lowest risk of Mycoplasma contamination for your fermentation process
• High performance 0.1 μm Mycoplasma retentive filter
• Fully validated as sterilizing-grade filter (according to current ASTM F-838 guideline)

Main Applications

Focus applications include:

• Cell culture media containing vegetable peptone, soy or yeast
• Serum containing cell culture media
• Cell Culture Media Components
• All other cell culture media used in biotechnical production

Your Benefits

• Increased total throughput leads to less filter consumption, less process interruptions and reduced costs
• Increased effective filtration enables the use of smaller filters to reduce footprint and waste
• Proven and robust membrane chemistry known from the widely established Sartopore® 2 family lowers validation effort in case of process optimization
• Broad range of formats and sizes assures scalability and enables use of Sartopore® 2 XLM along the whole drug product lifecycle: from development to commercial processes
• Offers secure bacterial retention according to ASTM guidelines

The XL family

The XL in its name indicates an increased effective filtration area (EFA). By using a different pleating technology, the EFAs of Sartopore ® 2 XLM filters are - depending on filter format - 30-40% higher than for the conventional Sartopore® 2 filters. This leads to higher total throughput per filter element and less filter consumption or enables the use of a smaller filter element for a process to reduce the footprint and waste.

Membrane

Sartopore^® 2 XLM uses a heterogeneous double membrane made of polyethersulfone

Compatibility

Sartopore^®2 XLM Cartridges have been developed for sterilization using either autoclaving or in-line-steaming. The polyethersulfone membrane used is suitable for the filtration of liquids in the pH range of pH 1-14.

Economical Filtration

The built-in pre-filter membrane is specially designed to protect the 0.1 μm membrane in cell culture media filtration. The optimized membrane combination together with the exceptionally high filter area of 0.8m²/10'' filter element allow a >50% better performance compared to existing 0.1 μm filter elements, which ensures low filtration costs per litre, minimized filtration times and smallest footprint of the filtration system.

Flexibility

Sartopore^® 2 XLM filters are available in a wide range of filtration areas from 4.5 cm² up to 2.4 m² and with a variety of commonly used connections to ensure easy integration into your process regardless of batch size.

Scale Up:

Consistent and predictable scale-up and scale-down procedures can be performed safely because all Sartopore^® filter elements are manufactured with the same membrane type and construction materials.

Quality:

Every single element is tested for integrity to meet the highest quality requirements.

Microbial Retention

Sartopore^® 2 XLM filter cartridges are validated as sterile filter cartridges according to HIMA and ASTM F-838-05 guidelines.

Documentation:

Sartopore^® 2 XLM filters have been designed, developed and produced in accordance with the ISO 9001 certified quality management system. A validation manual is available in accordance with regulatory requirements.