Sartopore® 2 XLG Capsule Size 4
Sartopore® 2 XLG Capsule is a sterile delivered PES membrane filter in a single-use housing and performs sterilizing-grade filtration of small volumes in bioprocesses. Its unique membrane composition boosts the filtration efficiency in downstream processing of proteins or lipid nanoparticles.
- EFA: 0.021 m² | 0.22 ft²
- Pore Size: 0.8 µm | 0.2 µm
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Sartopore® 2 XLG
Sartopore® 2 XLG is a high-performance membrane filter, offering more than just reliable sterilizing-grade filtration in biopharmaceutical processes. Its highly asymmetric membrane structure and composition of 0.8µm prefilter in front of the sterilizing-grade filter (0.2 µm pore size), boosts the filtration efficiency in downstream processing of protein-based therapies or innovative drug delivery systems like lipid nanoparticles (LNPs). Thanks to the outstanding total throughput, Sartopore® 2 XLG is also a choice for filtration after the cell harvest.
The XL in its name indicates an increased effective filtration area (EFA). By using a different pleating technology, the EFAs of Sartopore ® 2 XLG filters are - depending on filter format - 30-40% higher than for the conventional Sartopore® 2 filters. This leads to higher total throughput per filter element and less filter consumption or enables the use of a smaller filter element for a process to reduce the footprint and waste.
Sartopore® 2 XLG filters are available in all established formats with different sizes and for different purposes: Conventional filter cartridges for stainless steel housings or single-use capsules like the small Capsules, the mid-sized Midicaps®, the larger Maxicaps® / T-Style Maxicaps® and the Maxicaps® MR for very large volumes (e.g, clarification after bioreactor harvest). The single-use capsules are available as pre-sterilized (by autoclaving), autoclavable or gamma irradiatable versions. The wide range of different filter formats and sizes ensures that customers can easily scale up their process during drug development process – from preclinical to commercial scale.
- Cell culture media preparation
- Post cell harvest filtration
- Protein-based therapies (Downstream intermediates, form & fill)
- Lipid nanoparticles (Downstream intermediates, form & fill)
- Increased total throughput leads to less filter consumption, less process interruptions and reduced costs
- Increased effective filtration enables the use of smaller filters to reduce footprint and waste
- Proven and robust membrane chemistry known from the widely established Sartopore® 2 family lowers validation effort in case of process optimization
- Broad range of formats and sizes assures scalability and enables use of Sartopore® 2 XLG along the whole drug product lifecycle: from development to commercial processes
- Offers secure bacterial retention according to ASTM guidelines
ApplicationHigh capacity platform for conventional sterile filtration
IndustryPharma / Biotech
Bacterial RetentionQuantitative Retention of 1 × E7 CFU/cm² Brevundimonas Diminuta ATCC® 19146 per ASTM methodology
Bacterial Endotoxins< 0.25 EU/mL as determined by the LAL test
Biological ReactivityAll materials of this filter element meet the requirements of the current USP Biological Reactivity tests <88> for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).
ExtractablesThe total amount of extractables is well below the limits established by the current USP unter "Sterile Water for Injection".
Connector Inlet1/4" NPT-Male Thread
Connector Outlet1/4" Multiple Stepped Hose Barb
ConnectorsNTP ¼“ male | Hose Barb ¼“ multiple stepped
Filter Sizesize 4 (0.021 m² / 0.22 ft²)
Filtration Area0.021 m²
Outer Diameter63 mm (46 mm without Connection / Valves)
Capsule/Cartridge FormatCapsules Size 4&5
Maximum Allowable Back Pressure2 bar (29 psi) at 20°C; 1.5 bar (21.8 psi) at 50°C
Maximum Diffusion1.1 mL/min at 2.5 bar | 36 psi at 20 °C
Minimum Required Bubble Point3.2 bar | 46 psi
Materials of Construction
Housing MaterialPolypropylene (PP)
Material o-ring | sealSilicone (SI)
Membrane MaterialPolyethersulfone (PES)
Support FleecePolypropylene (PP)
Maximum Differential Pressure20 °C: 4 bar; 50 °C: 2 bar
Maximum Operating Pressure4 bar (58 psi)
Non-Fiber ReleasingThis filter product complies with the title 21 of the Code of Federal Regulations (CFR), section 210.3(b)(6) and 211.72.
Pore Size Final-filter0.2 µm
Pore Size Pre-filter0.8 µm
BrandSartopore® 2 XLG
Sterilization ProceduresAutoclaving: at 134°C, 30 min, 2 bar, min. 5 Cycles
The Sartocheck® 5 Plus Filter Tester is an automatic filter integrity tester with automated Quality Risk Management (QRM) designed to cover the complete range of integrity testing from small syringe filters up to large multi-round housings and tangential flow cassettes.
All members of the Sartoguard family utilize a highly asymmetric polyether sulfone (PES) membrane double layer for unmatched protection of final filters and bioburden reduction with an LRV of 6 per cm². In addition, combinations with different depth filter materials and gamma sterilizable versions are available.