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CMM HyperCel resin is composed of a rigid cellulose matrix that has flow properties compatible with the needs of manufacturing scale protein production.
The proprietary ligand, containing both a primary amine and a carboxyl group, confers cation exchange and hydrophobicity properties to the chromatography resin. The flexibility of the ligand enables the separation of proteins with a large variety of isoelectric points and hydrophobicity levels, and multiple conditions can be employed to separate targeted molecules from contaminants.
Features and Benefits
- Unique selectivity
- High capacity mixed-mode chromatography resin
- High recovery, low elution volume
- Easy CIP, NaOH stable
Applications
- Capture of MAbs, Fab fragments and recombinant proteins from challenging feedstocks
- Separation of proteins with similar isoelectric point and | or hydrophobicity at low or high conductivity
Compliance Information
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Quality StandardsCoA
Dimensions
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Bead Size50 - 80 µm
Materials of Construction
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Base MatrixRigid cellulose beads
Operating Conditions
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Maximum Operating Pressure< 3 barg (44psi)
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Operating Pressure< 3 barg (44psi)
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pH Stability1 to 14 (short term), 2 to 13 (long term)
Physicochemical Information
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LigandAminobenzoic acid
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Reference Protein
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Bovine serum albumin (BSA)
- Human polyclonal IgG
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Bovine serum albumin (BSA)
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Typical Dynamic Binding Capacity 10% per mL> 50 mg/mL BSA at pH 4.5, 15 mS/cm; 60-100 mg/mL IgG at pH 4 to 5, 4-12 mS/cm
Product Information
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BrandCMM HyperCel
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Resin Delivery Condition1M NaCl with 20% EtOH
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Resin TypeMixed-mode cation exchanger
Storage Conditions
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Storage Conditions20% EtOH/1M NaCl