CIMmic®

CIMmic^® is a line of small monoliths that provide an easy, budget‑friendly way to perform monolith chromatography using standard lab equipment. It offers an effortless way to start your process development.

The CIMmic line is the accessible entry point into CIM monolith chromatography for laboratories that need fast, flexible, and meaningful process development at small scale. Designed for early-stage method development and focused parameter screening, CIMmic helps scientists evaluate purification conditions without the need for complex automation, large sample volumes, or extensive chromatography infrastructure.

CIMmic is especially well suited for early process development teams working with valuable or limited biological samples. Whether you need to test purification feasibility, compare a small number of conditions, or generate early data before moving into broader screening, scale-up, or GMP-oriented process development, CIMmic provides a practical format for these needs by allowing you to perform real monolith chromatography experiments at a small scale.

CIMmic format can be used with a syringe or a standard FPLC system, leveraging equipment already available in many laboratories. This lowers the adoption barrier and lets teams start working with CIM monolith technology without investing in liquid-handling robots or specialized plate platforms. CIMmic offers a straightforward way to run chromatography experiments while maintaining flexibility in column operation.

CIMmic format is designed for screening a limited number of process parameters, such as buffer type, pH, conductivity, salt concentration, binding conditions, wash steps, and elution strategies. This makes it valuable in early downstream process development, where the goal is to identify promising conditions before committing to larger studies. CIMmic bridges the gap between simple small‑sample purification formats, such as spin columns, and higher‑throughput formats, such as CIM Octa or CIM monolithic well plates.

With interchangeable disks in the housing, the monolith volume can be adjusted between 0.1 and 0.3 mL. The format supports low material consumption while offering a chromatography‑representative format. This is important for applications involving high‑value biological materials, including viral vectors, plasmid DNA, RNA, viruses, virus‑like particles, proteins, and other large biomolecules.