Sartoclear® Depth Filter Cell Clarification and Contaminant Removal Technologies

The Sartoclear^® family is engineered from a trusted blend of cellulose and diatomaceous earth, providing a depth filter medium that has proven its effectiveness over time.

Key Features:

• Reliable Clarification: Depend on the Sartoclear^® for effective biomass separation, utilizing the well-regarded method of normal flow depth filtration for proven success.
• Ideal for screening up to commercial manufacturing: Discover the versatility of Sartclear^® for all your processing needs, from screening to commercial manufacturing, with our range of five convenient sizes.
• Quality Filtration Medium: The combination of cellulose and diatomaceous earth in the filter medium ensures a depth filter that consistently captures particulates, resulting in a clear filtrate.
• Scalable Results: The Sartoclear^® family is designed to provide scalable results, facilitating a smooth progression from small-scale and pilot processes to larger-scale production, ensuring a reliable pathway for process scaling.

Applications:

• Mammalian cell culture harvests
• Monoclonal antibodies (mAbs)
• Viral vectors (AAV; Adeno-associated virus)
• Microbial lysates
• Removal of precipitates from serum and plasma
• Particle and colloid removal from process intermediates

Double Layer Grades:

• DL90 (First Layer: 15 µm, Second Layer: 2 µm): For primary (coarse) clarification.
• DL75 (First Layer: 10 µm, Second Layer: 2 µm): For primary clarification, and in AAV clarification, it can serve as a single-stage solution followed by a sterilizing grade filter.
• DL60 (First Layer: 8 µm, Second Layer: 0.8 µm): For primary or secondary clarification, and in some cases, as a single-stage clarification solution followed by a sterilizing grade (e.g., AAV clarification).
• DL20 (First Layer: 0.8 µm, Second Layer: 0.4 µm): For secondary clarification post-depth filtration, -centrifuge or -perfusion.
• DL10 (First Layer: 0.8 µm, Second Layer: 0.1 µm): For secondary clarification post-depth filtration, -centrifuge or -perfusion.

Choose Sartoclear^® as your filtration solution to combine the reliability of proven techniques with the adaptability required for process development and commercial manufacturing. It represents the perfect balance between reliable results and convenient scalability.