Sartopure® GF Plus

Sartopure^® GF Plus Filters: Clarification and Prefiltration in Biopharma Processes

Sartopure^® GF Plus depth filters are designed for clarification and prefiltration in pharmaceutical and biopharmaceutical process streams. The two-layer adsorptive glass-fiber fleece supports reduction of colloids, lipids, protein aggregates and particles, helping protect downstream membrane filters, chromatography columns and ultrafiltration systems.

Main Formats:

• Retention Ratings: Available with 0.65 µm and 1.2 µm retention ratings, enabling selection according to feed stream composition, particulate load and downstream process requirements.
• Filter Cartridges: Designed for use in stainless steel housings and suitable for scalable clarification and prefiltration setups.
• Maxicaps^® and T-Style Maxicaps^®: Ready-to-use capsule formats for single-use process lines, pilot-scale applications and manufacturing workflows where enclosed filtration units are preferred.
• Midicaps^® and Mini Cartridges: Compact formats for small-volume processing, process development, scale-down studies and limited-volume biopharmaceutical applications.
• Jumbo Star Cartridges: Large-area filter format for process-scale clarification where higher filtration capacity and compact system integration are required.
• Sartoscale: Small-scale format for process development, filter selection and scale-up studies using the Sartopure^® GF Plus filter material concept.

Applications:

• Cell Culture Harvest Clarification: Used to reduce particles, colloids, lipids and protein aggregates in harvested cell culture fluids.
• Fermentation Broth Prefiltration: Suitable for clarification steps before downstream membrane filtration or purification.
• Media and Serum Filtration: Applicable for serum-containing media and other process fluids with colloidal or lipid-based contaminants.
• Viscous Solution Clarification: Can be used for large-volume parenteral and ophthalmic solutions with higher particulate or turbidity burden.
• Downstream Process Protection: Helps reduce particulate and colloidal load before membrane filters, chromatography columns and ultrafiltration systems.

Materials Used:

• Filter Medium: Two-layer adsorptive glass-fiber fleece for combined mechanical and adsorptive retention.
• Support Material: Polypropylene support fleece.
• Construction: Polypropylene core, end caps and capsule housing components, depending on the selected format.
• O-Rings: Silicone as standard, with EPDM or fluoroelastomer options depending on configuration and process requirements.

Advantages:

• Adsorptive Depth Filtration: Two-layer glass-fiber matrix supports reduction of colloids, lipids, protein aggregates and particles.
• Process Stream Clarification: Helps lower turbidity and particulate burden before downstream filtration or purification steps.
• Downstream Filter Protection: Can support extended use of subsequent membrane filters by reducing challenging contaminants upstream.
• Format Flexibility: Cartridge and capsule options support use from development scale to manufacturing scale.
• Single-Use Integration: Maxicaps^®, T-Style Maxicaps^® and Midicaps^® can be integrated into disposable process assemblies.
• Sterilization Options: Cartridges can be autoclaved or steam sterilized in-line; capsule formats can be autoclaved within specified operating limits.
• Application Range: Suitable for clarification tasks involving cell culture harvests, fermentation broths, serum-containing media and viscous pharmaceutical solutions.

Together, these features make Sartopure^® GF Plus a flexible depth filtration choice for clarification, prefiltration and downstream process protection in pharmaceutical and biopharmaceutical workflows.