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Tangential Flow Filtration (TFF) (1157)
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Tangential Flow Filtration (TFF) SystemsProduct Family
TFF Systems - Process Solutions for Ultrafiltration and Diafiltration
Sartorius offers flexible tangential flow filtration (TFF) systems for process development and clinical trials up to commercial production batches.
The TFF portfolio can flex to accommodate individual requirements, with a range of options that include cost-efficient multi-use systems or closed systems with single-use flow kits for bioburden reduced processing.Key Features
Availability of benchtop to production scale systems
Flow rate starting from 1 L/hr up to 5,000 L/hr depending on the system
Working membrane sizes from 50 cm² to 14 m² (optional up to 21 m²)
Single-use and multi-use
Highly- to fully automated
Compliancy to cGMP available -
Sartocon® and Sartocube® | TFF Ultrafiltration | CassettesProduct FamilySartorius TFF Ultrafiltration cassettes offer optimal solutions for UF/DF applications. Our two high-performance membranes — PES and Hydrosart® — both available in multiple cut-offs, ensuring the perfect fit for your process needs from lab to manufacturing scale.
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Sartocon® and Sartocube® | TFF Microfiltration | CassettesProduct Family
Membrane Materials: Hydrosart® or Polyethersulfone
Effective Filtration Areas: 0.02m² - 3m²
Pore Sizes: 0.1µm | 0.2µm | 0.45µm
Screen Types: Open Channes | Wide Spacer -
Ambr® CrossflowProduct Family
Study factors for manufacturability
Collect important information about the behaviour of the molecules in downstream processing already in an early stageAutomated, parallel trials
Up to 16 channels can be managed by one control stationLowest process volumes
Small scale screening with 10 cm² membrane area | 5 mL recirculation volumeFlexibility of two different process scales
Mid-scale screening is also possible with Sartocon® Slice 50 which has 50 cm² membrane area
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Sartocon® and Sartocube® | TFF Ultrafiltration | Self-ContainedProduct FamilySartocon® and Sartocube® self‑contained units are ready‑to‑use devices for sterile and aseptic processing. With Hydrosart® or PES membranes, they enable efficient UF/DF applications and are delivered pre‑flushed and sterile, eliminating pre‑use preparation.
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Sartoflow® 150 SU Flow KitsProduct Family
The Sartoflow® 150 single-use TFF flow kit for use with the Sartoflow® 150 system:
Faster change-over between different products.
More efficient and productive system use.
Increased facility flexibility.
Increased productivity per sqm manufacturing space.Key Features of the System
Flexibility to run various types of TFF modules and cassettes.
Designed to generate scalable data for use in small-scale production and process development.
Reliable scale-up to larger scale SUTFF systems
Disclaimer: Please note that the Sartoflow® 150 system is discontinued and its successor is the Sartoflow® Expert Single-Use system. Sartoflow®150 flow kits remain available.
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Hollow Fiber TFFProduct FamilyExperience ultra- and microfiltration performance with our Hollow Fiber TFF modules. Designed to balance between fiber stability and integrity as well as performance for optimal efficiency, these modules are ideal for a wide range of bioprocessing and pharmaceutical applications.
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Tangential Flow Filtration (TFF) Filter HoldersProduct Family
Key Features of the TFF Filter Holders
Self-draining and self-venting thanks to vertical positioning
Large retentate channels for low pressure drop
Easy installation
Low hold-up volume
Monolithic design
All ports located on the product plate -
Sartoflow® Expert Single-Use Flow KitsProduct Family
Sartoflow® Expert SU System with Precision-Engineered Flow Kits
Sartoflow® Expert flow kits are designed to enable the operational capabilities of the Sartoflow® Expert SU system. These flow kits play a crucial role in achieving optimal tangential flow filtration (TFF) performance.
Engineered for seamless integration, these single-use kits provide efficiency and reliability, ensuring that your processes are optimized for productivity and quality.Features & Benefits
Bioburden reduced
Chemical compatibility
Spill-free process and disassembly
Reduced hands-on time
No cleaning and validation effort -
Sartoflow® 4500 SU Flow KitsProduct Family
Key Facts
The Sartoflow® 4500 single-use flow kit is designed for the Sartoflow® 4500 TFF system.
Single-use design
Gamma irradiated
Controlled environment manufacturing
Quick installationBenefits
Fast turnaround: Quickly switch between products without extensive cleaning.
Reduced risk: Minimize contamination and product carryover.
Precise monitoring: Integrated sensors ensure accurate process control. -
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Sartoflow® 1000 Single-Use Flow KitsProduct FamilyThe Sartoflow® 1000 single-use flow kit is designed specifically for the Sartoflow® 1000 system, these flow kits offer efficiency and safety in multi-product facilities.
Disclaimer: For more information on the system, please contact your local Sartorius representative.Features & Benefits of the Flow Kit:
Fast turnaround.
Reduced cleaning validation.
Minimized bioburden risk and product carryover in a multi-product facility.
Enhanced productivity. -
Item no.Pore Size0.1 µmFiltration Area0.6 m²Membrane MaterialPolyethersulfone (PES)PriceItem no.Pore Size0.1 µmFiltration Area0.6 m²Membrane MaterialPolyethersulfone (PES)Item no.Pore Size0.1 µmFiltration Area200 cm²Membrane MaterialPolyethersulfone (PES)Item no.Pore Size0.1 µmFiltration Area0.1 m²Membrane MaterialPolyethersulfone (PES)
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Item no.MWCO1 kDaFiltration Area0.1 m²Channel HeightE-Screen (High viscosity)Price
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Item no.MWCO2 kDaFiltration Area200 cm²Channel HeightE-Screen (High viscosity)PriceItem no.MWCO2 kDaFiltration Area200 cm²Channel HeightE-Screen (High viscosity)
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