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Tangential Flow Filtration (TFF) (297)
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Sartoflow® Tangential Flow Filtration SystemsProduct FamilySartorius offers flexible tangential flow filtration (TFF) systems for process development and clinical trials up to commercial production batches.
The TFF portfolio can flex to accommodate individual requirements, with a range of options that includes cost-efficient multi-use systems or closed systems with single-use flow kits for bioburden reduced processing.
Benchtop to production scale from 100 mL to 200 L
Working membrane sizes from 10 cm² to 10 m²
Single-use and multi-use
Highly- to fully automated
Compliancy to cGMP available
Modular standard systems allow shorter lead times -
Sartocon® and Sartocube® | TFF Ultrafiltration | CassettesProduct Family
Membrane Materials: Hydrosart® or Polyethersulfone
Effective Filtration Areas: 0.02m² - 3.5m²
Cut-Offs: 1 - 300 kDa
Screen Types: E-Screen or ECO Screen -
Sartocon® and Sartocube® | TFF Microfiltration | CassettesProduct Family
Membrane Materials: Hydrosart® or Polyethersulfone
Effective Filtration Areas: 0.02m² - 3m²
Pore Sizes: 0.1µm | 0.2µm | 0.45µm
Screen Types: Open Channes | Wide Spacer -
Ambr® CrossflowProduct FamilyStudy factors for manufacturability
Collect important information about the behaviour of the molecules in downstream processing already in an early stage
Automated, parallel trials
Up to 16 channels can be managed by one control station
Lowest process volumes
Small scale screening with 10 cm² membrane area | 5 mL recirculation volume
Flexibility of two different process scales
Mid-scale screening is also possible with Sartocon® Slice 50 which has 50 cm² membrane area
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Sartoflow® Single-Use Flow KitsProduct FamilyKey Features & Benefits
Reduces preparation time
Decreases the need for cleaning validation and the risk of cross-contamination between different molecule productions
Enabels faster change-over between different products
More efficient and productive system use
Increased facility flexibility
Increased productivity per sqm manufacturing space -
Sartocon® and Sartocube® | TFF Ultrafiltration | Self-ContainedProduct Family
Self-Contained Unit (SCU): Pre-flushed, sterile and ready to use
Cut-Offs: 10 - 300 kDa
Effective Filtration Areas: 0.14 - 14m²
Membrane Material: Hydrosart® or Polyethersulfone
Channel Design: ECO
Connectors: AseptiQuik®
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Single-use LineProduct FamilyThe Hollow Fiber TFF Modules | Single-use Line offer a true single-use tangential flow filtration solution. A broad variety of different pore sizes and molecular weight cut-offs (MWCO) ensure a suitable solution for a wide range of processes. The scalability ranging from Lab- over Pilot- up to Process-scale increases flexibility in each stage of production. Hollow Fiber TFF Modules | Single-use are delivered gamma irradiated, fully integrity tested and therefore ready-to-use. Since, no cleaning is required you can save valuable time.
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Tangential Flow Filtration Filter HoldersProduct FamilyKey Features of the TFF Filter Holders
Self-draining and self-venting thanks to vertical positioning
Large retentate channels for low pressure drop
Easy installation
Low hold-up volume
Monolithic design
All ports located on the product plate
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