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Tangential Flow Filtration (TFF) (766)
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Tangential Flow Filtration (TFF) SystemsProduct Family
TFF Systems - Process Solutions for Ultrafiltration and Diafiltration
Sartorius offers flexible tangential flow filtration (TFF) systems for process development and clinical trials up to commercial production batches.
The TFF portfolio can flex to accommodate individual requirements, with a range of options that includes cost-efficient multi-use systems or closed systems with single-use flow kits for bioburden reduced processing.Key Features
Benchtop to production scale from 100 mL to 400 L (further sizes available upon request)
Working membrane sizes from 10 cm² to 14 m² (optional up to 21 m²)
Single-use and multi-use
Highly- to fully automated
Compliancy to cGMP available
Modular standard systems allow shorter lead times -
Sartocon® and Sartocube® | TFF Ultrafiltration | CassettesProduct Family
Membrane Materials: Hydrosart® or Polyethersulfone
Effective Filtration Areas: 0.02m² - 3.5m²
Cut-Offs: 1 - 300 kDa
Screen Types: E-Screen or ECO Screen -
Sartocon® and Sartocube® | TFF Microfiltration | CassettesProduct Family
Membrane Materials: Hydrosart® or Polyethersulfone
Effective Filtration Areas: 0.02m² - 3m²
Pore Sizes: 0.1µm | 0.2µm | 0.45µm
Screen Types: Open Channes | Wide Spacer -
Ambr® CrossflowProduct Family
Study factors for manufacturability
Collect important information about the behaviour of the molecules in downstream processing already in an early stageAutomated, parallel trials
Up to 16 channels can be managed by one control stationLowest process volumes
Small scale screening with 10 cm² membrane area | 5 mL recirculation volumeFlexibility of two different process scales
Mid-scale screening is also possible with Sartocon® Slice 50 which has 50 cm² membrane area
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Sartoflow® Single-Use Flow KitsProduct Family
Key Features & Benefits
Reduces preparation time
Decreases the need for cleaning validation and the risk of cross-contamination between different molecule productions
Enabels faster change-over between different products
More efficient and productive system use
Increased facility flexibility
Increased productivity per sqm manufacturing space -
Sartocon® and Sartocube® | TFF Ultrafiltration | Self-ContainedProduct Family
Self-Contained Unit (SCU): Pre-flushed, sterile and ready to use
Cut-Offs: 10 - 300 kDa
Effective Filtration Areas: 0.14 - 14m²
Membrane Material: Hydrosart® or Polyethersulfone
Channel Design: ECO
Connectors: AseptiQuik®
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Hollow Fiber TFFProduct FamilyExperience ultra- and microfiltration performance with our Hollow Fiber TFF modules. Designed to balance between fiber stability and integrity as well as performance for optimal efficiency, these modules are ideal for a wide range of bioprocessing and pharmaceutical applications.
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Sartoflow 1000 Single Use Flow KitsProduct FamilyThe Sartoflow® 1000 single-use flow kit is designed for the Sartoflow® 1000 TFF system sold in America.
Designed specifically for the Sartoflow® 1000 system, these flow kits offer efficiency and safety in multi-product facilities.
Disclaimer: For more information on the system, please contact your local Sartorius representative.
Features & Benefits of the Flow Kit.
Fast turnaround.
Reduced cleaning validation.
Minimized bioburden risk and product carryover in a multi-product facility.
Enhanced productivity.
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Sartoflow 150 SU Flow KitsProduct FamilyThe Sartoflow® 150 single-use TFF flow kit for use with the Sartoflow® 150 system:
Faster change-over between different products.
More efficient and productive system use.
Increased facility flexibility.
Increased productivity per sqm manufacturing space.
Key Features of the System
Flexibility to run various types of TFF modules and cassettes.
Designed to generate scalable data for use in small-scale production and process development.
Reliable scale-up to larger scale SUTFF systems
Disclaimer: Please note that the Sartoflow® 150 system is discontinued and its successor is the Sartoflow® Expert Single-Use system. Sartoflow®150 flow kits remain available. -
Sartoflow 4500 SU Flow KitsProduct Family
Key Facts
The Sartoflow® 4500 single-use flow kit is designed for the Sartoflow® 4500 TFF system, with a focus on the European | Asian market.
Single-use design
Gamma irradiated
Controlled environment manufacturing
Quick installationBenefits
Fast turnaround: Quickly switch between products without extensive cleaning.
Reduced risk: Minimize contamination and product carryover.
Precise monitoring: Integrated sensors ensure accurate process control. -
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Tangential Flow Filtration (TFF) Filter HoldersProduct Family
Key Features of the TFF Filter Holders
Self-draining and self-venting thanks to vertical positioning
Large retentate channels for low pressure drop
Easy installation
Low hold-up volume
Monolithic design
All ports located on the product plate -
Item no.Pore Size0.1µmFiltration Area0.6 m²Membrane MaterialPolyethersulfone (PES)PriceItem no.Pore Size0.1µmFiltration Area0.6 m²Membrane MaterialPolyethersulfone (PES)Item no.Pore Size0.1µmFiltration Area200 cm²Membrane MaterialPolyethersulfone (PES)Item no.Pore Size0.1µmFiltration Area0.1 m²Membrane MaterialPolyethersulfone (PES)
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