Sartopure® PP3: Polypropylene Prefilters for Efficient Particle Reduction in Biopharmaceutical Processes
Sartopure® PP3 is a polypropylene fleece-based prefilter platform for particle reduction in pharmaceutical and biopharmaceutical process streams. Designed for product-contact filtration, it helps reduce particulate load before downstream equipment and final membrane filtration steps. The multilayer fleece structure supports high dirt-holding capacity, while the all-polypropylene construction offers broad chemical compatibility and a low extractables profile.
Main formats:
- Filter cartridges: For installation in stainless steel housings and use in scalable process filtration setups.
- T-Style Maxicaps® and Maxicaps®: Ready-to-use capsule formats for process development, pilot-scale and manufacturing applications where enclosed formats are preferred.
- Midicaps® and Mini Cartridges: Compact formats for smaller process volumes, scale-up studies or limited-volume biopharmaceutical applications.
- Capsules: Small-scale formats for laboratory, development and low-volume filtration steps.
- Sartoscale Devices: Small-scale, ready-to-use screening devices for process development, filter selection and scale-up studies.
Applications:
- Downstream Filter Protection: Used as a prefilter to help reduce particulate burden before sterilizing-grade membrane filtration.
- Biopharmaceutical Clarification: Suitable for process streams in vaccine production, viral vector processing, including lentivirus applications, and other biopharmaceutical workflows.
- Pharmaceutical Filtration: Applicable for ophthalmic solutions, large-volume parenterals, antibiotics, solvents and other product-contact filtration steps.
- Process Flexibility: Available in multiple sizes, filtration areas and connector configurations to support development through manufacturing scale.
Materials Used:
- Filter Medium: Polypropylene fleece with multilayer fractionized retention for particle reduction and dirt-holding capacity.
- Construction: Polypropylene support, core and housing components, supporting compatibility with a broad range of process fluids.
- O-Rings: Silicone as standard, with EPDM or fluoroelastomer options depending on configuration and process needs.
Advantages:
- Broad Chemical Compatibility: All-polypropylene construction supports use with many acids, bases and solvents within specified operating conditions.
- Low Unspecific Binding: Helps support product recovery in sensitive biopharmaceutical process streams.
- Low Extractables Profile: Designed for regulated product-contact applications.
- High Dirt-Holding Capacity: Multilayer fleece design can help reduce required filtration area and prefilter consumption.
- Scalable Format Range: Multiple device formats support consistent filter selection from laboratory development to manufacturing.
- Sterilization Options: Suitable for autoclaving or in-line steam sterilization within the specified limits for the selected format.
Together, these features make Sartopure® PP3 a flexible prefiltration choice for particle reduction and downstream filter protection across biopharmaceutical and pharmaceutical processes.